Mutations in the secondary quinone electron acceptor (QB) pocket of the D1 protein conferring a modification on the donor side of photosystem II (PSII) have been characterized by gene cloning and sequencing in two metribuzin-resistant mutants of Synechocystis PCC 6714. The mutations induce different herbicide resistances: in M30, a point mutation at the codon 248, isoleucine to threonine, resul...

Human GWAS and Mendelian genetic studies have linked polymorphic variants and mutations in the human uromodulin gene (UMOD) with chronic kidney disease. The primary function of this kidney-specific and secreted protein remains elusive. This study investigated whether UMOD deficiency modified responses to unilateral ureteral obstruction (UUO)-induced kidney injury. Kidneys harvested from groups ...

BACKGROUND The inhibitory effects of black cohosh extracts (Cimicifuga syn. Actaea racemosa L.) on the proliferation of human breast cancer cells were reported recently. In this study, we turned examined another hormone-dependent, epidemiologically important tumor disease, prostate cancer. The cell growth inhibitory effect of an isopropanolic extract of black cohosh (iCR) on androgen-sensitive ...

Objective Tumour budding formed by histologically undifferentiated cancer cells beyond the border of the tumour margin is associated with lymph node metastasis. However, hollow tumour nests, a possible histologically advanced phenotype of tumour budding, have not been discussed. We examined whether hollow spheroids exist beyond the border of the invasive margin and are associated with metastasi...

Background: A new type of treatment is still needed for sporadic Alzheimer disease. The ion chelating agent (such as M30 and HLA-20) and other kinds of ion chelating agent possess brain tissue permeability. At present, the study has confirmed that ion chelating agent possesses a certain neuroprotective effect on neural degenerative disease. The objective of this study is to explore the related ...

BACKGROUND Intestinal ischemia-reperfusion (IR) is a phenomenon related to physiological conditions (e.g. exercise, stress) and to pathophysiological events (e.g. acute mesenteric ischemia, aortic surgery). Although intestinal IR has been studied extensively in animals, results remain inconclusive and data on human intestinal IR are scarce. Therefore, an experimental harmless model for human in...

A Magyar Nemzeti Múzeum Régészeti Örökségvédelmi Igazgatósága az M30-as számú gyorsforgalmi út Miskolcot Košice/Kassával összekötő szakaszának építési munkálatai során 2018. augusztus 28. és szeptember 19. között egy újkőkori település részleges feltárását végezte el Novajidrány, Szőlő-alja II. lelőhelyen. Az előzetes feldolgozás alapján előkerült mintegy 86, településhez, illetve temetkezéshez...

We study the globular cluster Terzan 4 projected close to the Galactic center, by means of V, I and Gunn z Colour-Magnitude Diagrams. The images were obtained under exceptional seeing conditions (0.35 "-0.55 ") at the ESO New Technology Telescope equipped with SUSI. We derive a reddening of E(B-V) = 2.35 amd a distance from the Sun d = 8.3 kpc for Terzan 4. From the similarity of the VI Colour-...