National Resilience esource Center © What works in prevention? This is the critical question substance abuse prevention programs face. Such inquiry invites new research agendas and leads to effective prevention programs. Working together, researchers and practitioners are discovering the answers. The success of this collaboration depends on admitting forthrightly what is not known. Knowing enou...

A plane domain Ω with more than one boundary point admits a hyperbolic metric and with respect to this metric, every holomorphic map of Ω into a subdomain X ⊆ Ω is a contraction. In this paper we define a new metric for the image domain X that is greater than or equal to the hyperbolic metric. Like the hyperbolic metric it has the property that any holomorphic map from Ω into X is a contraction...

Notice that best proximity point results have been studied to find necessaryconditions such that the minimization problemminx∈A∪Bd(x,Tx)has at least one solution, where T is a cyclic mapping defined on A∪B.A point p ∈ A∪B is a best proximity point for T if and only if thatis a solution of the minimization problem (2.1). Let (A,B) be a nonemptypair in a normed...

Using elementary hyperbolic geometry, we give an explicit formula for the contraction constant of skinning map over moduli spaces relatively acylindrical manifolds.

Secretion systems are essential for bacteria to survive and manipulate their environment. The bacterial type VI secretion system (T6SS) generates the force needed for protein translocation by the contraction of a long polymer called sheath. The sheath is a six-start helical assembly of interconnected VipA/VipB subunits. The mechanism of T6SS sheath contraction is unknown. Here, we show that elo...

Hedges, Jason C., Brian C. Oxhorn, Michael Carty, Leonard P. Adam, Ilia A. Yamboliev, and William T. Gerthoffer. Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle. Am J Physiol Cell Physiol 278: C718–C726, 2000.—Phosphorylation of h-caldesmon has been proposed to regulate airway smooth muscle contraction. Both extracellular signal-regulated kinase (ERK) and p38 mitogenactivated p...

  The effect of different doses (1-50 µ M) of imipramine (IMI) and desipramine (DES) on the rate and force of contraction of isolated rat atria was studied. IMI and DES produced a dose-dependent increase in force of contraction (31- 94% for IMI and 35-118% for DES). Pretreatment of rats with reserpine (5 mg/kg) on the isolated atria with propranolol (1 µ g) inhibited the positive ionotropic eff...

In this paper, we classify 8-dimensional manifolds M admitting an SU(3) action of cohomogeneity one such that (i) M is simply connected and the orbit space M/G is isomorphic to [0, 1], and (ii) M/G ∼= S and the principal orbits are simply connected. We discuss applications to the study of the group manifold SU(3) and to 8-dimensional quaternion-Kähler spaces. MSC classification: 57S25; 22E46, 5...

It has been conjectured that a manifold which is a homotopy sphere is topologically a sphere. This conjecture has implications, for example, in the theory of differentiate structures on spheres (see, e.g., [3, p. 33]). Here I shall sketch a proof of the following theorem: Let M be a piecewise-linear manifold of dimension n^7, which has the same homotopy-type as the n-sphere S. Then there is a p...

This paper considers the identi…cation and estimation of network models with agents interacting in multiple activities. We establish the model identi…cation using both linear and quadratic moment conditions. The quadratic moment conditions exploit the covariance structure of individuals’choices in the same and related activities, and facilitate the identi…cation of peer e¤ects when exclusion re...