A convenient method for the synthesis of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives was developed. A series of these compounds was synthesized and tested for substitution in the two-lever drug discrimination assay, in rats trained to discriminate injections of d-LSD tartrate (185.5 nmol/kg, ip) from saline. A dose-response curve for each of the compounds in the series was generate...

Aphasia i Charles Sym NPags TheFet-of Methe~d2riaedo egcAi Diethylaindeon Mental Processes-and onth BlooA&Adreafine Level. D. W.Ld HladI ei-ahre. . Investigaton of-Amnei Defects by PirogeWsve Proptiting. -Moyra Willia-ms. ..14' The Paresthesiae Indued by .C,ld. John Marshall . . . . .1 Affectie Epilesy. L. van-der Horst .. . . . .-.25 7 Th'e Epilepti Threshold in Schiophrenia. J. H -'iiand D. M...

The potency of hallucinogenic amphetamine derivatives of the 1-(2,5-dimethoxy-4-alkylphenyl)-2-aminopropane type drops dramatically when the length of the 4-alkyl substituent exceeds propyl or when the substituent is branched. This investigation was directed toward evaluating changes in behavioral and biochemical pharmacology resulting from introducing chirality into the 4-alkyl group of such a...

Background Recent survey data indicate that some people report long-term improvement in color vision deficiency (CVD), also known as blindness, following use of psychedelics such lysergic acid diethylamide (LSD) and psilocybin. However, there are no objective reported the medical literature quantifying degree or duration CVD associated with psychedelic use. Case presentation Here we present cas...

The role of drug efficacy in agonist-induced desensitization was studied in C-6 glioma cells transfected with the monkey dopamine D1A (mD1A) receptor. Dopamine pretreatment for 2 hr produced greater than 80% loss of responsiveness in the stimulation of cAMP accumulation that was blocked by the D1 antagonist SCH23390. A series of full and partial D1 agonists from structurally dissimilar classes ...

We analyze the 1496 days of SuperKamiokande data to put limits on the νe, ν̄e, νμ + ντ and ν̄μ + ν̄τ components of the diffuse flux of supernova neutrinos, in different energy intervals and for different neutrino energy spectra. By considering the presence of only one component at a time, we find the following bounds at 90% C.L. and for neutrino energy E > 19.3 MeV: Φνe < 73.3 − 154 cm−2s−1, Φν̄e <...