In vitro and in vivo lymphocyte function was studied in six patients with primary hypogammaglobulinaemia and nodular lymphoid hyperplasia (NLH) of the bowel. Lymphocyte transformation, numbers of circulating T and B lymphocytes, and delayed hypersensitivity skin tests did not significantly differ when compared with hypogammaglobulinaemic patients without NLH. However, patients with NLH had high...

Aims—To provide practical guidelines for the diVerentiation between benign and malignant focal lymphoid aggregates (lymphoid nodules) in routinely referred bone marrow trephine biopsies, using a synoptic approach including clinical data and histological workup. Methods—For easy identification of very small lymphoid infiltrates the chloroacetate esterase stain was applied as a screening procedur...

AIMS To provide practical guidelines for the differentiation between benign and malignant focal lymphoid aggregates (lymphoid nodules) in routinely referred bone marrow trephine biopsies, using a synoptic approach including clinical data and histological workup. METHODS For easy identification of very small lymphoid infiltrates the chloroacetate esterase stain was applied as a screening proce...

BACKGROUND To date, appropriate management for Bethesda IV thyroid nodules is controversial, and no specific features of follicular neoplasm and nodular hyperplasia on ultrasonography, computed tomography (CT), or other imaging modalities have been reported. This study aimed to compare CT features of follicular neoplasm and nodular hyperplasia and to determine the specific CT features that coul...

Prominent and localized lymphoid hyperplasia in the rectum is also known as rectal tonsil (RT) [1, 2]. When the reactive lymphoid infiltrate is very exuberant with atypical lymphoid cells it can be difficult to distinguish from lymphoma on histology [3]. To avoid overdiagnosis and overtreatment, immunophenotypic and genotypic studies are necessary [3–5]. A 4-year-old girl, without relevant medi...

A 58-year-old Japanese woman presented an eruption in the region of the back and the upper extremities, a subcutaneous nodule on the right breast, and a left cervical lymphadenopathy. The excision biopsy specimens, of a subcutaneous nodule and a lymph node, showed a vaguely nodular growth pattern comprising a small CD20 IgD lymphocyte infiltrate around clusters of medium-sized or large CD3 lymp...