Metastasis predominantly occurs via the lymphatic system in head and neck tumors. The disturbance of the lymphatic system in the cervical region resulting from neck dissection or radiotherapy may result in unusual patterns of metastasis in patients with recurrent tumors. This is more frequent when the recurrent tumor invades the myocutaneous flap used for the primary reconstruction. We encounte...

Hexokinase 1 (HK1) and pyruvate kinase M2 (PKM2) are two key regulators in glycosis and oncogenic markers in cancers. In the present study, we investigated the expression profile by Western blotting and immunohistochemistry and determined their prognostic values in the gastric cancer. Expression of HK1 and PKM2 was remarkably increased in gastric cancer tissues and was significantly associated ...

Adenoid cystic carcinoma is a rare malignant neoplasm of the salivary gland. Salivary gland neoplasms constitute 3% cancers all sites, which, 10–15% are malignant. Though adenoid most common tumor submandibular, sublingual and minor glands, it accounts for only 15% parotid cancers. They generally slow-growing spread relentlessly to adjacent structures. Hematogenous more than lymphatic spread, s...

Running title: EMILIN1 inhibits tumor growth and lymphatic spread Conflict of interest: No conflict of interest has to be disclosed. Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. EMILIN1 inhibits tumor growth and lymphatic spread 2 ABSTRACT The evidence that EMILIN1 deficiency in Emilin1-/-mice caused dermal and epidermal hyperproliferatio...

Among a total of 1259 patients with oesophageal cancer who underwent surgical resection, intramural metastasis (IMM) was verified in 93 patients (7.4%), of which IMM to the stomach (IMMS) constituted 13 patients (1.0%). In all 13 cases, the primary cancer was located in the middle or lower thoracic oesophagus and all had lymph nodes metastasis, while 12 of the 13 (92.3%) had lymphatic invasion....

Dysfunction of the immune system in colorectal cancer (CRC) can be due to a number of reasons including apoptosis of tumour infiltrating lymphocytes (TILs). The aims of this study were to characterize, phenotypically, the apoptosis of TILs in CRC, and define the association of these findings with prognostic indicators. We used double immunohistochemistry to assess the apoptosis of T-cell subset...

Because of the deficiency lymphatic reflux in tumor, retention tumor interstitial fluid causes aggravation pressure (TIP), which leads to unsatisfactory penetration nanomedicine. It is main inducement recurrence and metastasis. Herein, we design a pyroelectric catalysis-based Nano-lymphatic decrease TIP for enhanced treatments. realizes photothermal therapy decomposition under NIR-II laser irra...

PURPOSE The incidence of lymph node metastasis has been reported to range from 2.6 to 4.8% in early stage gastric cancer with mucosal invasion (T1a cancer). Lymph node metastasis in early stage gastric cancer is known as an important predictive factor. We analyzed the prediction factors of lymph node metastasis in T1a cancer. MATERIALS AND METHODS A total of 9,912 patients underwent radical g...

Согласно статистике, количество женщин с диагностированным раком молочной железы в мире на 2020 г. составило 2,3 млн чел. Количество смертей от рака примерно 690 000 (6,9 %) случаев. Около 70 % умерших имели метастазы. Одним из основных способов метастазирования считается лимфогенное распространение, что делает крайне необходимым понимание топографо-анатомических особенностей лимфатического рус...