Lymphadenopathy or often known as lymphatic disease is a that very risky if not handled properly. There are so many signs symptoms of this have been to the public, some even consider it an ordinary lump grows on human body and do know they experiencing lymphadenopathy in themselves [3]. Usually find out lump, examination hospital consult doctor. Based these problems, technique method needed can...

Sinus histiocytosis with massive lymphadenopathy (SHML) is a nonneoplastic, usually self limiting disease of unknown aetiology [1]. SHML most commonly presents as painless cervical lymphadenopathy with frequent involvement of other lymph nodes. In 30% of patients extranodal sites such as skin, bone, eye, and breast are involved [2]. Evidence of various immunological dysfunctions has also been d...

Rosai-Dorfman disease is a self-limiting condition caused by histiocyte proliferation within the sinusoids of lymph nodes and in extranodal tissue. It is a rare disease, particularly in children, that progresses with extensive lymphadenopathy. This paper reports on the case of a 2-year-old child with progressive cervical lymphadenopathy associated with persistent fever and radiological findings...

a 55-year-old man presented with pain in the left flank for the last 8 months with history of significant weight loss. the pain was relieved on assuming a knee-chest position. on clinical examination the patient was afebrile with mild tenderness in the left hypochondrium. there was no icterus or lymphadenopathy. the spleen was palpable 6 cm below the costal margin and was firm and non-tender. t...

The clinical signs of congenital toxoplasmosis are now well known, but those of post-natally acquired infections have received less attention. Sabin (1941) recorded two cases which presented as meningoencephalitis, and Pinkerton and Henderson (1941) described two cases which resembled typhus. In 1951 Siim reported seven cases which had generalized lymph node enlargement not unlike glandular fev...

MANY SEROLOGICAL surveys using the dye test of Sabin and Feldman (1948) have shown infection with Toxoplasma gondii to be widespread. It occurs with various degrees of frequency in different geographic areas and antibodies have been found in man and many species of animals (Feldman and Miller, 1956; Beattie, 1957; Jacobs, Remington and Melton, 1960; Ludlam and Beattie, 1963). As an infection pr...

Hepatosplenic T-Cell lymphoma (HSTCL) is a rare form of extra-nodal post-thymic T-cell non-Hodgkin's lymphoma that primarily involves liver and spleen with B symptoms, with a characteristic absence of lymphadenopathy. We report such an entity in a 65-year-old man who was diagnosed to have multiple myeloma and treated for the same for two years. A clinical diagnosis of secondary myelofibrosis wa...

Angioimmunoblastic lymphadenopathy (AILD) is a lymphoproliferative disorder with well established clinical and histological features, one of the clinical manifestations being a peripheral polyarthritis. A case of AILD with a symmetrical non-erosive peripheral polyarthritis is described, including the findings in the synovial fluid and histology of the synovium. There was a marked reduction in t...

Autoimmune lymphoproliferative Syndrome (ALPS) is a rare inherited disorder of apoptosis. It usually presents with chronic lymphadenopathy, splenomegaly, and symptomatic cytopenia in a child. Herein, we report a 14-year-old boy with symptoms misdiagnosed as hemophagocytic lymphohistiocytosis who was treated before ALPS was diagnosed for the patient. This case should alert pediatricians to consi...

Sinus histiocytosis with massive lymphadenopathy also called as Rosai-Dorfman’s disease is a benign self limiting rare histiocytic disorder with very few case reports in Pakistani literature. This case report describes a young boy of nine years age who presented with progressive, asymptomatic bilateral cervical lymphadenopathy for eight months. Open cervical lymph node biopsy confirmed the diag...