BACKGROUND It is well established that hypertensive patients with left ventricular (LV) hypertrophy have impaired diastolic filling. However, the impact of antihypertensive treatment and LV mass reduction on LV diastolic filling remains unclear. METHODS AND RESULTS Echocardiograms were recorded in 728 hypertensive patients with ECG-verified LV hypertrophy (Cornell voltage-duration or Sokolow-...

OBJECTIVES This study aimed to examine whether a history of asthma from childhood is associated with left ventricular (LV) mass in adulthood. BACKGROUND Asthma has been related to various cardiovascular risk factors affecting LV hypertrophy. The authors saw a need for a prospective study to analyze the relationship between a history of asthma from childhood and markers of LV mass among asympt...

PURPOSE To evaluate the accuracy of manually and automatically segmented true fast imaging with steady-state precession (FISP) and fast low-angle shot (FLASH) cine magnetic resonance (MR) imaging in the determination of left ventricular (LV) mass. MATERIALS AND METHODS Nine dogs and five pigs underwent cine MR imaging of the entire LV from base to apex. Manual and automatic segmentation times...

AIM To characterize the extent to which metabolic syndrome criteria predict left ventricular (LV) structure and function. METHODS AND RESULTS Metabolic syndrome criteria were assessed in 607 adults with normal LV function. The cohort was grouped according to the number of criteria satisfied: (1) Absent (0 criteria, n = 110); (2) Pre-Metabolic Syndrome (1-2 criteria, n = 311); and (3) Metaboli...

Left ventricular (LV) hypertrophy, a marker for adverse cardiovascular events, is more common in blacks than in non-Hispanic whites. Mechanisms leading to LV hypertrophy and mediating its clinical sequelae in blacks are not fully understood. We investigated the associations of 39 candidate biomarkers in distinct biological pathways with LV mass and geometry in blacks. Participants included 1193...

Objective: Our goal was to develop a technique for volumetric analysis of real-time three-dimensional echocardiography (RT3DE) data aimed at quantification of LV mass and validate it against magnetic resonance (MR) assumed as “gold standard”. Design: RT3DE, which has recently become widely available, provides dynamic pyramidal data structures that encompass the entire heart and allows four-dime...

BACKGROUND To evaluate the effect of lifestyle intervention in conjunction with rosiglitazone or placebo therapy on left ventricular (LV) mass, using cardiovascular magnetic resonance (CMR) in the metabolic syndrome. METHODS The present study was a pre-specified substudy of a double-blind randomized controlled trial evaluating the effect of lifestyle intervention in conjunction with rosiglita...

Estimation of left ventricular (LV) mass has both prognostic and therapeutic value independent of traditional risk factors. Unfortunately, LV mass evaluation has been underestimated in clinical practice. Assessment of LV mass can be performed by a number of imaging modalities. Despite inherent limitations, conventional echocardiography has fundamentally been established as most widely used diag...

Different combinations of volume and pressure overloads cause different left ventricular (LV) geometric adaptations. Whereas this cause-effect relationship is obvious for valve disease, because clear-cut types of overloads are easily recognizable, in systemic hypertension the type of cardiac load is less evident but at least as important for LV adaptation. Human arterial hypertension encompasse...