Objectives Lung cancer tumors are known to be highly lymphophilic. There two different pattern of lymphatic drainage the lung: one peribronchial pathway, and another within visceral pleura which appears more intersegmental than pathway. We aimed assess prevalence an pathway in lung determine potential influential factors. Methods In this prospective study, we included all patients for whom a ma...

Introduction: Lung cancer is one of the most common causes of cancer-related deaths worldwide. Nowadays PET/CT plays an essential role in radiotherapy planning specially for lung tumors as it provides anatomical and functional information simultaneously that is effective in accurate tumor delineation. The optimal segmentation method has not been introduced yet, however several ...

gastroesophageal reflux disease (gerd)  is defined with clinical symptoms  of  heart burning and regurgitation. it may be associated with external esophageal symptoms such as chronic cough, asthma, laryngitis, chronic lung disease, sinusitis and pulmonary fibrosis. in the present study, rats with chronic aspiration of gastroduodenal contentswere studied for  cellular phenotypes  and  cytokine c...

BACKGROUND We have demonstrated that soy isoflavones radiosensitize cancer cells. Prostate cancer patients receiving radiotherapy (RT) and soy tablets had reduced radiation toxicity to surrounding organs. We have now investigated the combination of soy with RT in lung cancer (NSCLC), for which RT is limited by radiation-induced pneumonitis. METHODS Human A549 NSCLC cells were injected i.v. in...

Introduction: Inflammatory myofibroblastic pseudotumors are initially described in the lung and various extrapulmonary sites such as the orbits, palatine tonsils, ears, gingiva, pterygomaxillary space, and periodontal tissues. These tumors rarely involve the larynx and predilection to the glottis occurs in an indolent manner.   Case Report This case describes a laryngeal myofibroblastic tumor i...

Abstract Aims: To investigate the effect of Myrtenol, the active ingredient of Myrtle, on the oxidant and anti-oxidant indices and cytokines in the allergic asthma. Methods: Allergic asthma was induced by ovalbumin (OVA) sensitization and inhalation in four groups of rats; Control, Asthma, Asthma+Dexamethasone and Asthma+Myrtenol. Myrtenol (50mg/kg) or Dexamethasone (2.5mg/kg) was a...

Context: The relationship between polymorphisms in the location of cytokine tumor necrosis factor (TNF-α) and lung cancer has been investigated many studies. Accordingly, present meta-analysis study focused on TNF-α-238 gene cancer. Methods: Articles were collected from Google Scholar, Scopus, PubMed electronic databases until 2022. articles searched based keywords “Lung cancer,” “238 Gene”, “t...

Abstract Small cell lung cancer (SCLC) is classified as a high-grade neuroendocrine (NE) tumor, but subset of SCLC has been termed “variant” due to the loss NE characteristics. In this study, we computed scores for patient-derived lines and xenografts, well human tumors. We aligned properties with transcription factor-defined molecular subtypes. Then investigated different immune phenotypes ass...

PURPOSE Angiogenesis inhibitors have strong therapeutic potential as antitumor agents in suppressing tumor growth and metastatic progression. Vasostatin, the N-terminal domain of calreticulin, is a potent angiogenesis inhibitor. In this study, we determined the effectiveness of vasostatin delivered by recombinant pseudotype adeno-associated virus 2/5 (rAAV2/5-VAS) as a gene therapy approach for...

By using the newly developed adhesive tumor cell culture system, we analyzed the chromosomal constitutions of primary lung tumor and nonmalignant normal lung tissue from 10 previously untreated patients with non-small cell lung cancer. Chromosomal analyses were successfully carried out in banded chromosome preparations from 10 tumor and 8 normal lung tissue samples. All analyzed tumor and norma...