Arthritic joints are chock-full of activated immune cells. These cells produce chemotactic proteins that lure other cells into the joint, setting up a vicious cycle of inflammation. But what instigates this cycle in the first place? A study by Kim et al. (page 829) puts much of the blame on neutrophils. Neutrophils—granular cells that are among the immune system’s earliest responders during inf...

Diagnosis of cholangiocarcinoma (CCA) is difficult when patients do not show jaundice. The aim of this study was to examine the feasibility of using the total serum bile acid (TSBA) level as an aid for the diagnosis of CCA in patients without jaundice. For this purpose, TSBA of the following groups were measured using a Beckman Synchron CX4 clinical chemistry analyzer: 60 cases of CCA with tota...

Motivated by the inverse problem for the Lemâıtre-Tolman-Bondi dust solution, in which problem the luminosity distance function DL(z) is taken as an input to select a specific model, we compute the function DL(z) of the LTB solution up to the third order of z. To perform the otherwise cumbersome computation, we introduce a new convenient form of the LTB solution, in which the solution is explic...

The Hamiltonian H of the Kepler-like equation of the LTB cosmological model is considered. The Schrödinger operator Ĥ obtained by canonical quantization of H, is assumed to govern the Schrödinger equation for the wave function ψ of the LTB universe. The scheme, that still depends on the arbitrary integration functions E(r), m(r) of the cosmological model, is integrated exactly. The eigenvalues ...

BACKGROUND Leukotriene-like immunoreactivity has been detected in exhaled breath condensate (EBC), but definitive evidence for the presence of leukotrienes (LTs) in this biological fluid is not available. A study was undertaken to determine whether LTC(4), LTD(4), LTE(4), and LTB(4) are measurable in EBC by gas chromatography/mass spectrometry and to quantify exhaled LTs in adults and children ...

BACKGROUND Leukotriene B4 (LTB(4)) has a key role in the pathophysiology of rheumatoid arthritis (RA). OBJECTIVE To investigate the inhibition of ex vivo LTB(4)-induced Mac-1 (CD11b/CD18) expression in leucocytes of patients with RA by the new oral LTB(4) receptor antagonist BIIL 284. METHODS The pharmacokinetics and inhibition of LTB(4)-induced Mac-1 expression of BIIL 284 were characteris...

The study objective was to determine the effect of feeding food enriched in (n-3) fatty acids (FA) on plasma FA profiles and leukotriene B (LTB) synthesis by stimulated peripheral blood neutrophils from dogs. For 36 weeks, two groups of dogs (n = 5) were fed food that contained either a low ratio of (n-6)-(n-3) FA (1.31:1; fish oil-enriched food) or a high ratio of (n - 6)-(n-3) FA (40.6:1; cor...

The purpose of this study was to investigate the relationship between birth weight and appetite related hormones, insulin resistance, and antioxidant status in overweight children aged 9-10 years. Thirty-four healthy overweight children (18 boys, 16 girls) were evaluated with respect to anthropometric measurement, lipid profiles, leptin, ghrelin, glucose, insulin, C-peptide, lipid soluble vitam...

In this paper we explore the possibility to find exact solutions for Teleparallel Gravity (TG) of type spherically symmetric Lema\^\i tre-Tolman-Bondi (LTB) dust models. We apply LTB metric formalism in its extension $f(T,B)$ models, which can be seen it as analagous from Schwarzschild solution General Relativity. An is obtained compatible with a specific model whose observational constraints a...

Interleukin (IL)-4, IL-10, and IL-13, Th2 cell-derived cytokines, play major roles in the pathophysiology of allergic diseases. These cytokines up-regulate or down-regulate the production of arachidonic acid metabolites. In this study, we have investigated the effect of IL-4, IL-10, IL-13, and other cytokines on A23187-stimulated synthesis of leukotriene (LT) B(4) in human polymorphonuclear leu...