A series of pyridazinone derivatives (19-34) were synthesized with an aim to synthesize safer anti-inflammatory agents. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation (LPO) actions. The percentage inhibition in edema at different time intervals indicated that compounds 20, 26, 28 and 34 exhibited good anti-inflammatory potential, comparab...

Two widely used antipsychotic drugs, chlorpromazine (CPZ) and trifluoperazine (TFZ) inhibit NADPH-induced microsomal lipid peroxidation (LPO). Study of microsomal membrane fluidity revealed considerable disorganization in its architecture in the presence of NADPH, which can be restored back in the presence of CPZ and TFZ. NADPH-dependent microsomal LPO is catalyzed by NADPH: cytochrome P450 red...

[1] The development of Lattice Preferred Orientations (LPO) within olivine aggregates under flow in the upper mantle leads to seismic and rheological (or viscoplastic) anisotropies. We compare predictions from different micromechanical models, applying several commonly used theoretical descriptions to an upwelling flow scenario representing a typical oceanic spreading center. Significant differ...

The follicular fluid environment surrounding the oocytes may play a critical role in fertilization and subsequent embryo development. The goal of our study was to evaluate the oxidative stress markers in the semen, blood serum, and follicular fluid of couples undergoing Intracytoplasmic Sperm Injection (ICSI). Two hundred and eight infertile couples underwent ICSI and the levels of superoxide d...

Manganese (Mn) is a chain-breaking antioxidant in biological systems. The objective of the present study was to determine the optimal dose of Mn to reverse free radical-mediated oxidative damage on motility, viability, and lipid peroxidation (LPO) of sperm from five bulls (local crossbred cattle). Fresh semen was suspended in 2.9% sodium citrate, divided into equal fractions, and subjected to M...

To evaluate the influence of ω-6/ω-3 poly unsaturated fatty acid (PUFA) containing oils on lipid profile and endogenous antioxidant enzymes in normal and stressed (immobilization) rats, 28 day old male Wistar rats were fed for 45 days with fat enriched special diet (10% fat) prepared with sunflower oil (SO)  ω-6 rich, mustard oil (MO)  ω-3 rich and groundnut oil  control respectively. SO tre...

H(2)O(2) formation by Streptococcus mitis was measured by the catalase-dependent conversion of [(14)C]formate to (14)CO(2) ; it was optimal at pH 6.0-6.5 and required glucose. The H(2)O(2) formed by S. mitis could be employed as a component of an antimicrobial system that also included lactoperoxidase (LPO) and either iodide or thiocyanate ions in the concentrations present in saliva. The antim...

BACKGROUND Oxidative stress mechanisms are involved in the pathophysiology of many reproductive disorders. The objective of this study was to characterize oxidative stress parameters in hydrosalpingeal fluid (HSF) and examine their possible role in early embryo development. METHODS AND RESULTS HSF was aspirated at laparoscopic salpingectomy in 11 infertile women. Reactive oxygen species (ROS)...

Oxidative stress is a key feature in the Alzheimer's disease (AD) brain and manifests as lipid peroxidation (LPO). Isoprostanes (iPs) are specific and sensitive markers of in vivo LPO. To determine whether amyloid beta (Abeta) deposition in vivo is associated with increased LPO, we examined iP levels in a transgenic mouse model (Tg2576) of AD amyloidosis. Urine, plasma, and brain tissues were c...

The role of glutathione (GSH) in cellular antioxidant systems has long been recognised especially for protection against membrane lipid peroxidation (LPO). Several enzymes using glutathione have been implicated in such protection including GSHPx, PHGPx and GSH Stransferases. Such enzymes may or may not be susceptible to acute regulation [ 1-3 1 . We have further explored GSH mediated inhibition...