نتایج جستجو برای: lox tank

تعداد نتایج: 17601  

Journal: :Cancer research 2002
Dawn A Kirschmann Elisabeth A Seftor Sheri F T Fong Daniel R C Nieva Colleen M Sullivan Elijah M Edwards Pascal Sommer Katalin Csiszar Mary J C Hendrix

We identified previously an up-regulation in lysyl oxidase (LOX) expression,an extracellular matrix remodeling enzyme, in a highly invasive/metastatic human breast cancer cell line, MDA-MB-231, compared with MCF-7, a poorly invasive/nonmetastatic breast cancer cell line. In this study, we demonstrate that the mRNA expression of LOX and other LOX family members [lysyl oxidase-like (LOXL), LOXL2,...

2000
Dayuan Li Jawahar L. Mehta

A specific lectinlike endothelial receptor for oxidized low density lipoprotein (LOX-1), distinct from the scavenger receptor in monocytes/macrophages, has been identified and cloned. In this study, we examined the regulation of LOX-1 by oxidized low density lipoprotein (ox-LDL) and determined the role of LOX-1 in ox-LDL–induced apoptosis of cultured human coronary artery endothelial cells (HCA...

Journal: :American journal of physiology. Heart and circulatory physiology 2010
Xiuping Chen Hanrui Zhang Steve McAfee Cuihua Zhang

We hypothesized that the reciprocal association between adiponectin and lectin-like oxidized LDL (ox-LDL) receptor (LOX)-1 contributes to the regulation of aortic endothelial dysfunction in atherosclerosis. To test this hypothesis, endothelium-dependent (ACh) and endothelium-independent (sodium nitroprusside) vasorelaxation of isolated aortic rings from control mice, apolipoprotein E (ApoE) kno...

Journal: :Molecular cancer therapeutics 2002
Wei-Gang Tong Xian-Zhong Ding Richard C Witt Thomas E Adrian

Several studies have suggested that high dietary fat intake, particularly essential fatty acids, is associated with pancreatic cancer development and growth. Our previous studies have demonstrated that blockade of either the 5-lipoxygenase (LOX) or 12-LOX pathway of arachidonic acid metabolism inhibited pancreatic cancer cell proliferation and induced apoptosis. This study investigated the unde...

Journal: :Free radical biology & medicine 2015
Josefin Zschaler Juliane Dorow Louisa Schöpe Uta Ceglarek Jürgen Arnhold

Human 5-lipoxygenase (5-LOX) oxidizes arachidonic acid to 5S-hydroperoxy-6 E,8 Z,11 Z,14 Z-eicosatetraenoic acid (5-HpETE) and leukotriene (LT) A4. In neutrophils, LTA4 is further converted to the potent chemoattractant LTB4. These cells also contain the heme enzyme myeloperoxidase (MPO), which produces several potent oxidants such as hypochlorous acid (HOCl), which are involved in pathogen def...

1999
Hiroshi Ikawa Hideki Kamitani Benjamin F. Calvo Julie F. Foley Thomas E. Eling

Recently, we reported the induction of reticulocyte type 15-lipoxygenase (15-Lox-1) in a human colorectal carcinoma cell line that had been stimulated by butyrate to undergo apoptosis and cell differentiation (H. Kamitani et al., J. Biol. Chem., 273: 21569–21577, 1998). To determine if 15-Lox-1 is expressed in human colorectal cancer tissue, 21 matched pairs of colorectal tumor and adjacent nor...

Journal: :Hypertension 2012
Xianwei Wang Magomed Khaidakov Zufeng Ding Sona Mitra Jingjun Lu Yao Dai Jawahar L Mehta

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) regulates growth of a variety of cells and is important in inflammation, oxidative stress, and tissue remodeling. Recent studies show that LOX-1 deletion limits cardiac remodeling after sustained hypertension. We posited that LOX-1 may affect cardiac fibroblast growth and collagen secretion. To examine this postulate, we studied gr...

Journal: :International Journal of Molecular Sciences 2021

The constitutive expression or overactivation of cyclooxygenase (COX) and lipoxygenase (LOX) enzymes results in aberrant metabolism arachidonic acid poor prognosis melanoma. Our aim is to compare the vitro effects selective COX-1 (acetylsalicylic acid), COX-2 (meloxicam), 5-LOX (MK-886 AA-861), 12-LOX (baicalein) 15-LOX (PD-146176) inhibition terms proliferation (SRB assay), mitochondrial viabi...

Journal: :Journal of the experimental analysis of behavior 2011
Brian D Kangas Rachel N Cassidy

Thirty-five years ago, B.F. Skinner (1976) lamented a decreasing trend in the prevalence of cumulative records in the Journal of the Experimental Analysis of Behavior ( JEAB). The editorial began with the two memorable lines, ‘‘Evidently we have not long to wait for an issue of JEAB without a single cumulative record! I shall not miss the records so much as the kinds of experiments that could s...

2004
Schoffstall

Triboelektrostatická separácia minerálnej substancie zo slovenského uhlia V článku sú diskutované niektoré technické aspekty triboelektrostatickej separácie a výsledky aplikácie tohto postupu pri úprave troch typov uhlia, konkrétne energetického uhlia z Cígľa, Handlovej a Novák. Bolo zistené, že účinnosť separácie veľmi úzko závisí na druhu separovan uhlia. Prvé výsledky preukázali súvislosť me...

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