OBJECTIVES It is well known that familial hypercholesterolemia (FH) is a common inherited disorder that can markedly elevate the level of plasma LDL cholesterol. However, little data exists regarding the clinical impact of the plasma triglyceride (TG)-rich lipoprotein fraction, including VLDL and IDL, in FH. Thus, we assessed the hypothesis that the mutations in the LDL receptor modulate lipopr...

background: there is evidence that cd36 promotes foam cell formation through internalizing oxidized ldl (ox-ldl) into macrophages therefore, it plays a key role in pathogenesis of atherosclerosis. in addition, cd36 expression seems to be mediated by nuclear receptor peroxisome proliferator-activated receptor gamma (ppar-γ). the aim of the present study was to evaluate and compare the effect of ...

Very low density lipoproteins (VLDL), Sf60 to 400, from normolipemic individuals do not suppress 3-hydroxy-3-methylglutaryl-CoA reductase activity in cultured normal human fibroblasts at concentrations 20fold higher than those of low density lipoproteins (LDL) that give total suppression. To determine if these VLDL contain all of the structural elements necessary for receptor-mediated suppressi...

Dyslipidemia is a disease characterized by abnormalities in blood lipid levels, mainly total cholesterol and triglycerides. Other changes include low high-density lipoprotein (HDL-C) high levels of low-density (LDL-C)

Familial hypercholesterolemia (FH) is a common genetic cause of elevated low-density lipoprotein cholesterol (LDL-C) due to defective clearance circulating LDL particles. All FH patients are at high risk for premature cardiovascular disease (CVD) events their genetically determined lifelong exposure LDL-C levels. However, different rates CVD have been reported in patients, even among those with...

T he importance of lipid, lipoprotein, and apolipoprotein risk factors in the prediction, prevention, and regression of atherosclerosis is now well established. The role of elevated low density lipoprotein cholestexol (LDL C) in the development of coronary heart disease (CHD) is supported by evidence from numerous epidemiologic studies, clinical trials, and genetic studies.1-3 High density lipo...

Background: Coronary artery disease today is a major contributor to mortality and morbidity from cardiovascular disease. The drug, interventional and surgical methods are used to treat coronary artery stenosis. Statins are the most commonly used drugs for stenosis and coronary artery disease. Low-density lipoprotein (LDL) The purpose of this study was to evaluate the effect of atorvastatin on L...

www.aafp.org/afp AMERICAN FAMILY PHYSICIAN 871 1988, the National Cholesterol Education Program, Adult Treatment Panel I (NCEP–ATP I) developed its first set of guidelines, establishing clear goals for patients with lipid abnormalities. In 1993, the NCEP–ATP II revised its initial recommendations and developed a second set of guidelines; in addition to emphasizing CHD risk status, this report p...

CONTEXT Next to Alzheimer disease, vascular dementia is the second most common form of dementia in the elderly, yet few specific risk factors have been identified. OBJECTIVE To investigate the relationship of plasma lipids and lipoproteins to dementia with stroke. DESIGN AND SETTING Prospective longitudinal community-based study over a 7-year period (1991-1998). PARTICIPANTS A total of 11...

To determine if plasma lipoproteins interact and therefore possibly regulate intestinal lipoprotein metabolism, we investigated the binding, internalization, and degradation of 125I-labeled low density lipoprotein (LDL) and high density lipoprotein (HDL) by enzyme-dispersed rat intestinal mucosal cells. Both human and rat LDL and HDL were bound, internalized, and degraded in a concentration-dep...