accumulating evidence suggest that in patients with diabetes mellitus, increased rate of lipoprotein oxidation and oxidative stress have important role in diabetic angiopathy, including nephropathy. to evaluate the association of oxidized low- density lipoprotein (ox-ldl) with the development of diabetic nephropathy, plasma level of ox-ldl were measured in 70 diabetic patients with macro and 63...

liver secretes a large range of very low density lipoprotein (vldl) particles of different sizes and svedberg flotation rates (sf). in plasma vldl is converted to low density lipoprotein (ldl)which in turn plays an important role in the development of atherosclerotic diseases; however,triglyceride (tg) rich vldl1 has been shown to be more deleterious than cholesteryl ester (ce) rich vldl2. ther...

Submit Manuscript | http://medcraveonline.com Abbreviations: NP: Nano Particle; LDL: Low Density Lipoproteins ; HDL: High Density Lipoproteins ; SLDL: Synthetic Low Density Lipoproteins; LDL-Rl: Low Density Lipoprotein Receptor ; SR-Bi: Scavenger Receptor Class B Type I; DTPA: Diethylene Triaminepenta Acetic Acid; SPECT: Single-Photon Emission Computed Tomography; MRI: Magnetic Resonance Imagin...

Submit Manuscript | http://medcraveonline.com Abbreviations: NP: Nano Particle; LDL: Low Density Lipoproteins ; HDL: High Density Lipoproteins ; SLDL: Synthetic Low Density Lipoproteins; LDL-Rl: Low Density Lipoprotein Receptor ; SR-Bi: Scavenger Receptor Class B Type I; DTPA: Diethylene Triaminepenta Acetic Acid; SPECT: Single-Photon Emission Computed Tomography; MRI: Magnetic Resonance Imagin...

An inherited metabolic disorder in a strain of New Zealand White rabbits, characterized by marked hypercholesterolemia (394 +/- 100 mg/dl), with moderately elevated or normal triglyceride levels is described. Low density lipoprotein (LDL), intermediate density lipoprotein (IDL) and very low density lipoprotein (VLDL) cholesterol levels were increased. VLDL and IDL, and to a lesser extent LDL, h...

SUMMARY The cardiac lymphatic system of pigs was found to consist of valved efferent lymph vessels draining into a cardiac lymph node, which is similar to the lymphatic system found in dog and man. The interstitial lipoproteins of the heart were studied by sampling cardiac efferent lymph in anesthetized fasting pigs (n — 4) and dogs (n • • 5). In pigs, the lymph flow rate was 2.0 ± 0.7 ml/hr (m...

T he importance of lipid, lipoprotein, and apolipoprotein risk factors in the prediction, prevention, and regression of atherosclerosis is now well established. The role of elevated low density lipoprotein cholestexol (LDL C) in the development of coronary heart disease (CHD) is supported by evidence from numerous epidemiologic studies, clinical trials, and genetic studies.1-3 High density lipo...

Serum concentrations for the cholesterol and triglyceride content of very low density lipoprotein (VLDL) and the cholesterol content of intermediate density lipoprotein (IDL), low density lipoprotein (LDL), and the high density lipoprotein fractions (HDL2), HDL3) were measured in 337 men and women with the apo E phenotype who were born in the Grampian Region of North East Scotland. The subjects...

Background and aims: Mendelian randomization studies have shown that triglyceride (TG)- lowering lipoprotein lipase (LPL) alleles low-density lipoprotein-cholesterol (LDL-C)-lowering independent beneficial associations on cardiovascular disease (CVD) risk. We aimed to provide further insight into this observation by applying analyses of genetically-influenced TG LDL-C levels plasma metabolomic ...

Familial combined hyperlipidemia (FCHL) is a common inherited lipid disorder, affecting 1 to 2 percent of the population in Westernized societies. Individuals with FCHL have large quantities of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) and develop premature coronary heart disease. A mouse model displaying some of the features of FCHL was created by crossing mice carr...