Homologous recombination is an important mechanism for the repair of double-strand breaks in DNA. One possible outcome of such repair is the reciprocal exchange or crossing over of DNA between chromosomes. Crossovers are beneficial during meiosis because, as well as generating genetic diversity, they promote proper chromosome segregation through the establishment of chiasmata. However, crossing...

Cancer develops when cells no longer follow their normal pattern of controlled growth. In the absence or disregard of such regulation, resulting from changes in their genetic makeup, these errant cells acquire a growth advantage, expanding into pre-cancerous clones. Over the last decade many studies have revealed the relevance of genomic mutation in this process, be it by misreplication, enviro...

Dhanjoo N. Ghista1, U. Rajendra Acharya2, Kamlakar D. Desai3, Sarma Dittakavi4, Adejuwon A. Adeneye5 and Loh Kah Meng6 1Department of Graduate and Continuing Education, Framingham State University, Framingham, Massachusetts, 2School of Engineering, Division of ECE, Ngee Ann Polytechnic, 3Mukesh Patel School of Technology Management & Engineering, 4Biomedical Engineering department, Osmania Univ...

supplementary material WILLIAM LOH, ADAM A. S. GREEN, FRED N. BAYNES, DANIEL C. COLE, FRANKLYN J. QUINLAN, HANSUEK LEE, KERRY J. VAHALA, SCOTT B. PAPP, SCOTT A. DIDDAMS, Time and Frequency Division, National Institute of Standards and Technology, Boulder, CO, 80305, USA T. J. Watson Laboratory of Applied Physics, California Institute of Technology, Pasadena, CA, 91125, USA *Corresponding author...

Jenny U. Johansson,1 Suraj Pradhan,1,5 Ludmila A. Lokteva,1,2 Nathaniel S. Woodling,1,5 Novie Ko,6 Holden D. Brown,1 Qian Wang,1 Christina Loh,3 Egle Cekanaviciute,1,5 Marion Buckwalter,1,4 Amy B. Manning-Boğ,6 and Katrin I. Andreasson1 Departments of 1Neurology and Neurological Sciences, 2Molecular and Cellular Physiology, 3Microbiology and Immunology, and 4Neurosurgery, Stanford University Sc...

In diploid populations, indirect benefits of sex may stem from segregation and recombination. Although it has been recognized that finite population size is an important component of selection for recombination, its effects on selection for segregation have been somewhat less studied. In this article, we develop analytical two- and three-locus models to study the effect of recurrent deleterious...