نتایج جستجو برای: longitudinal relaxivity
تعداد نتایج: 127871 فیلتر نتایج به سال:
The relaxivity displayed by Gd(3+) chelates immobilized onto gold nanoparticles is the result of the complex interplay between the nanoparticle size, the water exchange rate and the chelate structure. In this work we study the effect of the length of ω-thioalkyl linkers, anchoring fast water exchanging Gd(3+) chelates onto gold nanoparticles, on the relaxivity of the immobilized chelates. Gold ...
Purpose: Superparamagnetic iron oxide (SPIO) contrast agents have been used for a number of years to label cells for tracking by MRI. However, these particles are significantly disadvantaged in longitudinal imaging because, as cells divide, the amount of iron per cell decreases and eventually the labeled cells can no longer be detected. MR reporter genes exist that allow cells to produce iron p...
BACKGROUND Liposomal-based gadolinium (Gd) nanoparticles have elicited significant interest for use as blood pool and molecular magnetic resonance imaging (MRI) contrast agents. Previous generations of liposomal MR agents contained gadolinium-chelates either within the interior of liposomes (core-encapsulated gadolinium liposomes) or presented on the surface of liposomes (surface-conjugated gad...
Combining sugar conjugates and DO3A-Gd complexes, paramagnetic gold glyconanoparticles (GNPs) with different relaxivity values were obtained and tested in vivo as MRI probes.
Macromolecular contrast agents have the potential to assist magnetic resonance imaging (MRI) due to their high relaxivity, but are not clinically useful because of toxicity due to poor clearance. We have prepared a biodegradable ketal-based polymer contrast agent which is designed to degrade rapidly at physiological pH by hydrolysis, facilitating renal clearance. In vitro, the agent degraded mo...
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