PURPOSE Meta-analyses of the published literature suggest a survival benefit to adjuvant chemotherapy for high-grade astrocytoma, which individual small trials have been unable to demonstrate reliably. The Medical Research Council Brain Tumour Working Party initiated the largest randomized trial of adjuvant chemotherapy for glioma in an attempt to provide a definitive answer. PATIENTS AND MET...

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A. J . KING*, K. A. WARD , P. O’CONNOR , D. GREEN , Z. TONKIN* AND J. MAHONEY* *Freshwater Ecology, Arthur Rylah Institute for Environmental Research, Department of Sustainability and Environment, Heidelberg, Vic., Australia Goulburn Broken Catchment Management Authority, Shepparton, Vic., Australia Forest Management, Department of Sustainability and Environment, Tatura, Vic., Australia Murray-...

BACKGROUND Treatment of recurrent anaplastic glioma and glioblastoma remains a particular challenge in neurooncology. The lack of controlled trials results in poor evidence for all therapeutic options. Upon recurrence, many patients are treated with bevacizumab or one of the frequently used nitrosoureas such as lomustine. However, patients who still present in overall good condition after failu...

1 Tumour Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia 2 Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia 3 Department of Pathology, The University of Melbourne, Parkville, VIC, Australia 4 Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia *Correspondence: ygal.haupt...