Background Telestroke is recognized as a safe and time-efficient way of treating stroke patients. However, admission centers (spokes) are subject to financial charges which can make them reluctant to join the system. We implemented and assessed an economic model supporting our telestroke system, Virtuall, France, which includes one expert center (hub) and six spokes. Methods The model is base...

Hub location problem (HLP) is one of the most important problems in the areas of logistics and telecommunication network design. In this paper we address the bi-objective non-strict single allocation hub location problem (BONSSAHLP). The non-strict property of this problem which allows establishment of direct links between pairs of non-hub nodes makes it somehow different from the conventional ...

UNLABELLED Hub proteins (those engaged in most physical interactions in a protein interaction network (PIN) have recently gained much research interest due to their essential role in mediating cellular processes and their potential therapeutic value. It is straightforward to identify hubs if the underlying PIN is experimentally determined; however, theoretical hub prediction remains a very chal...

conclusions our results revealed the possible crucial genes and mirnas involved in the initiation and progression of hcc cells infected with hcv. results based on the topological analysis of mirna-hubgene network, we identified the key hub mirnas. in order to identify the most important common sub-network, we aligned two ppi networks using netal tool. the c-jun gene was identified as the most i...

Regional Knowledge Hub for HIV/AIDS Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran DVM, Regional Knowledge Hub for HIV/AIDS Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Regional Knowledge Hub for HIV/AIDS Surveillance, Institute for Futures Studies in Health, Kerman Universi...

 We introduce a dynamic and stochastic transportation problem consisting of two subproblems. For parcel transportation in hub-and-spoke networks, swap containers are used to carry out hub-to-hub shipments. This constitutes a pickup and delivery problem on the operational level. On the tactical level, empty swap containers are balanced over the hub-network in order to match the stochastic deman...

In this paper an uncapacitated multiple allocation p-hub median problem is discussed. The model minimizes the transportation cost based on inventory service level at hubs through double paths between hubs. Inventory service level is defined as the percent of inventory shortage of vehicles at hubs according to passengers demand and replenishment time of vehicles. A real data from 25 nodes of mun...

To function properly, tissue-specific stem cells must reside in a niche. The Drosophila testis niche is one of few niches studied in vivo. Here, a single niche, comprising ten hub cells, maintains both germline stem cells (GSC) and somatic stem cells (CySC). Here, we show that lines is an essential CySC factor. Surprisingly, lines-depleted CySCs adopted several characteristics of hub cells, inc...