Using a novel approach for a two-locus model that provides a greatly increased power to detect multiple quantitative trait loci (QTLs) in simulated data, we identified in a sample of 961 female sib-pairs, three genome-wide significant QTLs for apolipoprotein A1 on chromosomes 8p21.1-q13.1 (LOD score 3.71), 9q21.32-33.1 (LOD score 3.28) and 10p15.1-p13 (LOD score 5.51), two for lipoprotein (a) o...

Genes contributing to common forms of hypertension are largely unknown. A number of studies in humans and in animal models have revealed associations between insulin resistance, dyslipidemia, and elevated hypertension. To identify genes contributing to blood pressure (BP) variation associated with insulin-resistant dyslipidemia, we conducted a genome-wide scan for BP in a set of 18 Dutch famili...

INTRODUCTION Late-onset disease with Group B Streptococcus (GBS LOD) remains a significant problem in neonates. Unlike early-onset disease, rates of GBS LOD have not changed with prenatal testing. Effects of GBS LOD can be severe and thus identifying risk factors for severe GBS LOD, such as hypervirulence genes, may help in managing these infants. CASE PRESENTATION We present a case of a neon...

In order to provide a streaming service of 3-D spatial objects to the mobile clients on a street, we propose a new query type, called continuous perspective query. The perspective query differs from conventional spatial queries in that the levels of details (LOD) of query results depend on the distance between the query point and spatial objects. The objects in the vicinity are to be provided w...

The genetic factors determining the magnitude of the response to exercise training are poorly understood. The aim of this study was to identify quantitative trait loci (QTL) associated with adaptation to exercise training in a cross between FVB/NJ (FVB) and C57BL/6J (B6) mice. Mice completed an exercise performance test before and after a 4-wk treadmill running program, and changes in exercise ...

Additional information on genetic susceptibility effects relevant to type 2 diabetes pathogenesis can be extracted from existing genome scans by extending examination to related phenotypes such as age at disease onset. In this study, we report the reanalysis of data from 573 U.K. sibships ascertained for multiplex type 2 diabetes, using age at onset (assessed by the proxy measure of age at diag...

Due to limitations of chemical analysis procedures, small concentrations cannot be precisely measured. These concentrations are said to be below the limit of detection (LOD). In statistical analyses, these values are often censored and substituted with a constant value, such as half the LOD, the LOD divided by the square root of 2, or zero. These methods for handling below-detection values resu...

Level of Development (LOD) is a protocol to address the basic guidelines information of Building Information Modeling (BIM). LOD is created to identify specific content requirements of a BIM model elements at a given time. It is used to reduce the problem of inadequate information needed in projects. This paper aims to explore the implementation of LOD in projects using BIM in the construction ...

CONTEXT Obesity is a growing health care problem worldwide and is a major underlying risk factor for common diseases such as diabetes. Parent-of-origin effect has been reported to be involved in the development of obesity. But the genes with imprinting effects related to obesity are largely unknown. OBJECTIVE The objective of the study was to identify obesity-related genetic loci, both with a...

Background: It is assumed in polycystic ovary syndrome (PCOS) that follicular development, maturation, ovulation and implantation are impaired due to hormonal imbalance and vascular impairment of the ovarian and uterine vasculatures. The mechanism of action of laparoscopic ovarian drilling (LOD) is largely unexplained. To date, only limited studies have been conducted utilizing 3D ultrasonograp...