One of the largest family of cell surface proteins, G-protein coupled receptors (GPCRs) regulate virtually all known physiological processes in mammals. With seven transmembrane segments, they respond to diverse range of extracellular stimuli and represent a major class of drug targets. Peptidergic GPCRs use endogenous peptides as ligands. To understand the mechanism of GPCR activation and rati...

Flexible piezoelectric acoustic sensors (f-PAS) have attracted significant attention as a promising component for voice user interfaces (VUI) in the era of artificial intelligence things (AIoT). The signal distortion issue highly sensitive biomimetic f-PAS is one most challenging obstacle real-life application, due to fundamental difference compared with conventional microphones. Here, noise-ro...

purpose: to compare general anesthesia (ga) with local anesthesia (la) in terms of safety and patient satisfaction. methods: in this interventional case series, 928 consecutive patients who underwent vitreoretinal surgery were included. data for analysis were type of anesthesia and operation, patient compliance, operating conditions and pain scores. general anesthesia was provided with a standa...

The transmembrane domains in a membrane protein must be recognized and correctly oriented before their insertion into the lipid bilayer. Devaraneni et al. (2011) generate snapshots at different stages of membrane protein biogenesis, revealing a dynamic set of steps that imply an unexpectedly flexible membrane insertion machinery.