AIMS This study aimed to investigate whether cabotegravir (CAB), an integrase inhibitor in development for treatment and prevention of human immunodeficiency virus-1, influences the pharmacokinetics (PK) of a levonorgestrel (LNG) and ethinyl oestradiol (EO)-containing oral contraceptive (OC) in healthy women. METHODS In this open-label, fixed-sequence crossover study, healthy female subjects ...

This paper presents a generic, high-level risk assessment of the global operation of ocean-going liquefied natural gas (LNG) carriers. The analysis collects and combines information from several sources such as an initial hazid, a thorough review of historic LNG accidents, review of previous studies, published damage statistics and expert judgement, and develops modular risk models for critical...

In this paper, an LNG BOG re-liquefaction system operating according to the Claude refrigeration cycle using oxygen as refrigerant is analysed. It includes a comprehensive exergy analysis of a BOG reliquefaction system installed onboard an LNG carrier. Commonly operating data have been used to carry out a thermodynamic analysis of the system. The system is basically made of two parts: Oxygen cy...

OBJECTIVE To assess the relative contraceptive effectiveness, tolerability and acceptability of the levonorgestrel-releasing (20 microg per day) intrauterine system (LNG-20) compared with reversible contraceptive methods in women of reproductive age. DESIGN A systematic review and meta-analysis of randomised controlled trials. IDENTIFICATION Studies were identified through seven databases, ...

Unintended pregnancy is a global reproductive health problem. Emergency contraception (EC) provides women with a safe means of preventing unwanted pregnancies after having unprotected intercourse. While 1.5 mg of levonorgestrel (LNG) as a single dose or in 2 doses with 12 hours apart is the currently gold standard EC regimen, a single dose of 30 mg ulipristal acetate (UPA) has recently been pro...

BACKGROUND/AIM This study aimed to compare the levonorgestrel intrauterine system (LNG-IUS) with abdominal hysterectomy (TAH) and total laparoscopic hysterectomy (TLH) as first-line treatments for heavy menstrual bleeding (HMB). MATERIALS AND METHODS Ninety-eight patients aged 20-55 years who complained of regular heavy menstrual bleeding were enrolled in the study. The TAH group included 29 ...

Federal safety regulations require the use of validated consequence models to determine the vapor cloud dispersion exclusion zones for accidental liquefied natural gas (LNG) releases. One tool that is being developed in industry for exclusion zone determination and LNG vapor dispersion modeling is computational fluid dynamics (CFD). This paper uses the ANSYS CFX CFD code to model LNG vapor disp...

iran’s vast common natural gas resources and the necessity to extract and export it as liquefied natural gas (lng) to distances more than 3000km opens a lucrative field for researchers to optimize lng cycles. in this article heat integration in cryogenic cycles by determining interacycle partition temperature and optimizing refrigeration features like subcooler, presaturator, aftercooler, reboi...