CONTEXT Most patients subjected to liver transplantation presents hypersplenism, which is reversed after the operation. However, some patients remain with moderate to intense hypersplenism. OBJECTIVES To study the effect of liver transplantation on platelet count in patients with hypersplenism. METHOD Of a total of 233 patients who underwent liver transplantation, 162 were excluded from the...

OBJECTIVE To evaluate the long-term impact of liver transplantation on ocular manifestations of familial amyloid polyneuropathy (FAP) in Japanese patients. METHODS Medical records were retrospectively reviewed in a long-term follow-up study. Of 52 patients with FAP amyloidogenic transthyretin Val30Met, 22 patients underwent liver transplantation. We assessed ocular manifestations, including a...

Invasive fungal infection (IFI) in liver transplant recipients is associated with poor outcomes. Targeted antifungal prophylaxis is recommended for high-risk populations; however, the epidemiology of IFI has changed, and the risk criteria remain unclear. In addition, the risk factors for late-onset invasive aspergillosis (IA) have not been fully characterized. We examined 279 recipients over 16...

Background Primary sclerosing cholangitis (PSC) is a progressive cholestatic liver disease, with liver transplantation being the sole life-saving treatment for end-stage PSC-related liver disease. However, recurrence of PSC after liver transplantation is a common complication, with the risk factors for recurrence being controversial. Methods We conducted a retrospective chart review of 45 pat...

One-third of patients with cirrhosis present kidney failure (AKI and CKD). It has multifactorial causes a harmful effect on morbidity mortality before after liver transplantation. Kidney function does not improve in all transplantation, transplant recipients are at high risk developing chronic disease. The renal dysfunction can be divided into three groups: pre-operative, perioperative post-ope...

The incidence rate of liver cancer is increasing year by globally. Liver transplantation has become one the therapeutic methods for patients with cancer. In past, ischemia-reperfusion injury (IRI) was unavoidable in transplantation, compromising recipient and graft survival. At same time, imbalance between supply demand organs limits use Recently, advances have been made machine perfusion techn...

22 23 Hepatitis C virus (HCV) reinfects liver allografts in transplant recipients, replicating 24 immediately after transplantation, followed by a rapid increase in serum HCV RNA 25 levels. We evaluated dynamic changes in the viral genetic complexity after HCV 26 reinfection of the graft liver and identified the characteristics of replicating HCV clones 27 using a massive-parallel ultra-deep se...

Liver transplantation was approved for treatment of decompensated cirrhosis in the United States in 1983. Hepatitis B and hepatitis C viruses are the leading causes of liver transplantation for viral hepatitis and hepatitis B is also an important cause of liver transplantation for called acute liver failure) due to either acute hepatitis B or an acute exacerbation of chronic hepatitis B. Howeve...

OBJECTIVES Liver transplantation has not increased with the number of patients requiring this treatment, increasing deaths among those on the waiting list. Models predicting post-transplantation survival, including the Model for Liver Transplantation Survival and the Donor Risk Index, have been created. Our aim was to compare the performance of the Model for End-Stage Liver Disease, the Model f...

Liver transplantation has revolutionized the care of patients with end-stage liver disease. Liver transplantation is indicated for acute or chronic liver failure from any cause. Because there are no randomized controlled trials of liver transplantation versus no therapy, the efficacy of this surgery is best assessed by carefully comparing postoperative survival with the known natural history of...