Background and Purpose: Liver transplantation is an ultimate therapeutic option for end-stage liver disease. In the context of liver cirrhosis caused by viral hepatitis, it is known that re-infection of the graft occurs frequently and that progression of fibrosis advances more quickly in the transplanted organ [1]. Therefore, a closer follow-up is necessary including frequent biopsies for gradi...

BACKGROUND Acute and chronic hepatitis E have been associated with high mortality and development of cirrhosis, particularly in solid-organ recipients and patients infected by human immunodeficiency virus. However, data regarding the epidemiology of hepatitis E in special populations is still limited. AIMS Investigate seroprevalence and possible factors associated with HEV infection in a larg...

BACKGROUND Polyomavirus reactivation can cause significant morbidity in solid organ transplant recipients, particularly BK virus (BKV) in kidney transplant patients. Less is known about dynamics of John Cunningham virus (JCV) in nonkidney organ transplant patients. METHODS We examined the frequency of urinary shedding of polyomaviruses BKV and JCV and their relationship to creatinine clearanc...

STUDY OBJECTIVE To examine the safety and efficacy of aerosolized pentamidine (AP) as alternative primary prophylaxis against Pneumocystis carinii pneumonia (PCP) in adult liver and kidney transplant recipients. DESIGN Retrospective review of medical records. SETTING Tertiary care urban teaching hospital with active liver and kidney transplant programs. PATIENTS Adult liver and kidney tra...

background: cytomegalovirus (cmv), a problematic virus in solid organ transplant recipients (sotr) such as liver, can worsen overall mortality and transplant outcome, so its prevention and treatment is a key of success in such patients. this study is aimed to compare the efficacy of ganciclovir (gcv) and valganciclovir (vgc) for prevention and treatment of infection with cmv. materials and meth...

BACKGROUND AND AIMS  Colorectal cancer (CRC) is associated with a significantly reduced survival rate in transplant recipients. The prevalence and risk factors of CRC and of colorectal polyps after orthotopic liver transplant (OLT) remain unclear. The study aim was to determine the prevalence of colorectal polyps in OLT recipients. A secondary objective was to explore possible risk factors of p...

Background and aimLiver transplants cases have been rising becoming the choice of treatment for many patients with end stage liver diseases. With an increasing number qualified centers facilities, effectiveness observed to increase over years. But success quality life post transplant has be influenced due psychiatric comorbidities.MethodWe searched literature using terms ‘Psychosocial factors’,...

OBJECTIVES In this study, we examined the activities of key peroxisomal enzymes in peripheral blood lymphocytes (PBLs) of pediatric liver transplant patients. SUBJECTS AND METHODS Venous blood was drawn from 14 patients aged 5-16 years on FK-506 treatment and 18 healthy subjects for isolation of lymphocytes. β-Oxidation of very long chain fatty acids (VLCFAs) and activities of superoxide dism...

BACKGROUND The burden of liver disease in the UK has risen dramatically and there is a need for improved diagnostics. AIMS To determine which breath volatiles are associated with the cirrhotic liver and hence diagnostically useful. METHODS A two-stage biomarker discovery procedure was used. Alveolar breath samples of 31 patients with cirrhosis and 30 healthy controls were mass spectrometric...

New-onset diabetes after transplantation (NODAT) is common after liver transplant and associated with poorer outcomes. The aim of this study was to identify risk factors for NODAT in liver transplant recipients off corticosteroids. In 225 adult nondiabetic liver transplant recipients, the mean age was 51.7 years, the majority were men (71%), and half had HCV (49%). The mean calculated MELD scor...