PURPOSE: Spin labeling (SL) MRI is a non-invasive technique for perfusion evaluation. Drug-related risks, which is a concern in contrast-enhanced MRI, are eliminated by using labeled blood as endogenous contrast. In a few studies SL-MRI of the liver has been explored [1-5]. However, in humans only readouts with a single post labeling delay (PLD) were used, limiting quantification accuracy. The ...

This study assessed the utility of CT perfusion for quantitative assessment of liver function and fibrosis. Tissue blood flow (TBF), tissue blood volume (TBV), mean transit time (MTT) and hepatic arterial fraction (HAF) were measured with CT perfusion using the deconvolution algorithm in 38 patients with chronic liver diseases and 10 patients without liver disease. Using Child-Pugh classificati...

BACKGROUND N-acetylcysteine (NAC) has been shown to improve splanchnic blood flow in experimental studies. This report evaluates the effects of NAC on liver perfusion and lactate signal intensities in the liver tissue of septic shock patients using proton magnetic resonance imaging and spectroscopy. Furthermore, the monoethylglycinexylidide (MEGX) test was used to investigate hepatic function. ...

Background: Hepatic ischemia/reperfusion injury (I/RI) is a multifactorial pathophysiologic process which can lead to liver damage and dysfunction. This study examined the protective effect of dexamethasone on the gene expression of endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) and on the liver tissue damage during warm hepatic I/R. Materials and Methods: A total of 32 mal...

Abstract Introduction Normothermic machine perfusion (NMP) is a method of organ preservation that aims to replicate the physiological environment, achieved by perfusing livers with blood-based perfusate at inflow pressures and temperature. NMP also permits viability assessment through evaluation flow rates portal vein hepatic artery. In addition this, biochemical gas analysis can be performed p...

Objective. Evaluate the main criteria for ASL-liver perfusion in viral hepatitis. Material and methods . 111 patients with hepatitis, including 69 (62.2%) men 42 (37.8) women, were examined on basis of “Clinical hospital N 1”, Smolensk. The average age was 48 ± 5.4 years. All subjects (n = 111) underwent abdominal ultrasound Doppler vascular examination, clinical elastography, magnetic resonanc...

1. The influence of ethanol on the metabolism of livers from fed and starved rats has been studied in liver-perfusion experiments. Results have been obtained on oxygen consumption and carbon dioxide production, on glucose release and uptake by the liver and on changes in the concentrations of lactate and pyruvate and of beta-hydroxybutyrate and acetoacetate in the perfusion medium. 2. Oxygen co...

Fifty consecutive patients with colorectal cancer but no evidence of secondary deposits in the liver were included in an ongoing controlled clinical trial of adjuvant liver perfusion aimed at reducing the incidence of hepatic metastases. All patients had their primary tumour resected in the standard way. Twenty-six of the patients served as controls, and 24 received fluorouracil, 1 g daily, as ...

CONTEXT Liver transplantation is one of the last viable resources for patients with end-stage liver disease. Many strategies are been used to improve the number of available organs and overcome waiting list delay. However, hepatic steatosis is one of the mainly concerns when organs are consider to transplantation due to it is importance as a risk factor for primary dysfunction. Surgeons play an...

K. G. Hollingsworth, M. J. Graves, D. J. Emmens, D. J. Lomas Radiology, University of Cambridge & Addenbrooke's Hospital, Cambridge, United Kingdom, Medical Physics, Addenbrooke's Hospital, Cambridge, United Kingdom Introduction Hepatic perfusion can be altered by the development of fibrosis and cirrhosis or lesions, and the ability to accurately quantify perfusion may be clinically significant...