Myotonic dystrophy type 1, also known as Steinert's disease, is a multisystemic disorder with significant genetic and clinical heterogeneity. Apart from skeletal muscles' myotonia and wasting, a variety of system organs can be affected. We report on a 49 years old female patient with unremarkable medical and family history, who presented with elevated liver enzymes without signs or symptoms of...

Liver Disease-Bouchier et al. MEDICAL JOURNAL gamma-globulin and that, in liver disease, the antibody is frequently a macroglobulin, while in D.L.E. it is predominantly a 7S gamma-globulin (Weir and Holborow, 1962). Positive A.N.F. tests were found in the absence of a positive L. Mackay and Wood, 1962). Unlike Calabresi and Greenberg's (1960) findings, antinuclear antibodies were not found in t...

Serum glycocholic acid (SGC) was measured by radioimmunoassay in 277 samples from 122 children with hepatobiliary disorders and from 23 healthy age-matched controls. In patients with hepatobiliary disease the SGC was more frequently abnormal (83%) than values for serum albumin (7%), prothrombin time (17%), bilirubin (22%), alkaline phosphatase (45%), aspartate transaminase (57%) and gammaglutam...

disease, so many cases of liver disease are now identified in individuals incidentally found to have abnormal liver function tests (LFTs) as part of routine automated laboratory testing. Abnormal LFTs cannot be ignored because a subgroup of these patients will have progressive and potentially life-threatening liver disease for which therapeutic interventions are often available. Even in an asym...

Abstract Untreated sewage and industrial wastes from Faisalabad city are disposed to River Chenab through Chakbandi Main Drain (CMD). The present project is planned investigate the effects of this freshwater pollution on body fish Ictalurus punctatus. specimens species were collected upstream downstream entrance CMD into Chenab. Fish gills, liver, kidney muscles dorsolateral regions subjected h...

PURPOSE NT-proBNP has emerged as a powerful diagnostic and prognostic biomarker in heart disease. Studies showed that NT-proBNP is a sensitive biomarker for identifying patients with heart failure caused by hepatitis C virus (HCV) related myocarditis. The purpose of this study was to evaluate the correlation between the serum concentration of NT-proBNP and hepatitis virus infection/liver diseas...

We investigated lipid and lipoprotein abnormalities in SHRSP fatty rats as a new animal model of metabolic syndrome. We examined differentially expressed genes in the liver, one of the major tissues contributing to lipid metabolism. Using gel filtration high performance liquid chromatography, increased cholesterol concentrations of small particle size low-density lipoprotein (LDL) fractions wer...

A 40-year-old woman was admitted with altered consciousness and hyperammonemia after she had delivered her first baby. DNA analysis of the citrin gene and enzymatic assay of argininosuccinate synthetase in the liver led to a diagnosis of adult-onset type II citrullinemia (CTLN2). She was also found to have hepatocellular carcinoma (HCC) and underwent palliative surgery consisting of partial liv...

During the post-mortem examination of a young Hindu male, who had committed suicide by hanging on the 25th instant, I noticed the following abnormality of the liver, which was otherwise healthy. A small pedunculated oliveshaped lobule was attached by a thick root to the left border of the spigelian lobe at the junction of its anterior and middle thirds. This lobule was ? inch long by f inch in ...

A 59-year-old woman presented with a burning, rapidly progressive mass on the midchest, occurring after a fall 4 months prior. Examination found a large well-circumscribed mass over the lower xiphisternum (Figs 1 and 2). Results of baseline investigations were normal apart from mildly elevated liver function values. A computerized tomography scan confirmed a 6.4x 4.9-cm lobulated soft tissue he...