Abstract Liposomes are used widely as drug delivery systems in different forms including nanosuspensions, osmotic pumps, infusion pumps and IV injections. Some of these systems (e.g. infusion or osmotic pumps) might stay stagnant for a long time during or before administration, and therefore, might face phase separation. In spite of these, there is no data available about the behavior of lipos...

Abstract Liposomes are used widely as drug delivery systems in different forms including nanosuspensions, osmotic pumps, infusion pumps and IV injections. Some of these systems (e.g. infusion or osmotic pumps) might stay stagnant for a long time during or before administration, and therefore, might face phase separation. In spite of these, there is no data available about the behavior of lipos...

Combination formulations of liposomes with collagen have been previously introduced as a means of obtaining more stable and less permeable liposomes. In this study, the effect of aqueous solutions of the collagen products COLLAPUR? (COL) and COLLAPURON-DAK? (COLD) from Henkle Co., on the release rate of sodium chromate (CHR) as a water-soluble model drug from stable plurilamellar vesicles (SPLV...

The aim of current study was to investigate the effect of Brij decoration of liposomes on in vitro and in vivo characteristics of the nanocarriers. Two hydrophilic Brij surfactants (Brij 35 and Brij 78) with almost similar molecular weight but differing in acyl chain were incorporated into liposomal bilayers at two percentages (5% and 10%). Conventional liposomes (CL) containing egg phosphatidy...

Multilamellar phosphatidylcholine liposomes (0.1 pmol) and 1 : 1 phosphatidylcholinecholesterol multilamellar liposomes (0.094pmol) were incubated with 2 x lo6 unstimulated CBA mouse peritoneal macrophages in Fisher's medium. A, Phosphatidylcholine liposomes+macrophages ; 0, phosphatidylcholine liposomes alone; A, phosphatidylcholins-cholesterol liposomes+maaophages; 0, phosphatidylcholin~holes...

Background: Non-viral Nano carriers such as liposomes and cationic polymers based on engineered properties are regarded in gene delivery field. Although these carriers do not have weaknesses of viral vectors, but they are less efficient than viruses and they still need to be improved as favorable gene delivery carriers. Amongst non-viral carriers, cationic liposomes have been proposed for clini...

The obtaining of nanocarriers gene material and small drugs is still an interesting research line. Side-effects produced by the toxicity several pharmaceutics, high concentrations needed to get therapeutic effects, or their excessive use patients have motivated search for new nanostructures. For these reasons, cationic metallo-liposomes composed phosphatidylcholine (PC), cholesterol (CHO) RuC1C...

The purpose of this study is to evaluate in vitro gene delivery mediated by asialofetuin-appended cationic liposomes (AF-liposomes) associating cyclodextrins (CyD/AF-liposomes) as a hepatocyte-selective nonviral vector. Of various CyDs, AF-liposomes associated with plasmid DNA (pDNA) and γ-cyclodextrin (γ-CyD) (pDNA/γ-CyD/AF-liposomes) showed the highest gene transfer activity in HepG2 cells wi...

Liposomes are spherical vesicles consisting of one or more concentric phospholipid bilayers enclosing an aqueous core. Being both nontoxic and biodegradable, liposomes represent a powerful delivery system for several drugs. They have improved the therapeutic efficacy drugs through stabilizing compounds, overcoming obstacles to cellular tissue uptake increasing drug biodistribution target sites ...

The objective of this work was to evaluate the physical properties and in vivo circulation of chitosan (CH)-coated liposomes of mitoxantrone (MTO). Changes in particle size and zeta potential confirmed the existence of a coating layer on the surface of liposomes. The in vitro release of adsorbed CH from the liposomes was significantly slower than CH solution, indicating the stable interaction b...