نتایج جستجو برای: liposomal gel

تعداد نتایج: 111845  

Journal: :iranian journal of pathology 2009
mohsen mirzaee parviz owlia mohammad reza mehrabi amir gharib

background and objectives:  the most common problems limiting the medical use of aminoglycosides have been the nephro- and oto-toxicities as well as the increasing bacterial resistance. encapsulation of drugs into liposomes enhances their efficacy while reducing their toxicities. the aim of this study was to evaluate the antimicrobial activity of free and liposomal amikacin. material and method...

Journal: :Biological & pharmaceutical bulletin 2004
Yasutami Shigeta Hiromichi Imanaka Hideya Ando Atsuko Ryu Naoto Oku Naomichi Baba Taketoshi Makino

Linoleic acid (LA) is known to have a whitening effect on hyperpigmented skin, and is encapsulated in liposomes for topical application because of its low solubility in aqueous solution, although the effect of liposomalization of LA on the whitening activity has not been evaluated. In the present study, we evaluated the effect of liposomalization on the whitening activity of LA by using LA in e...

Journal: :Indian journal of experimental biology 2009
M K Bhalaria Sachin Naik A N Misra

Aim of this work was to prepare and characterize fluconazole (FLZ) encapsulated ethosomes, incorporate it in suitable dermatological base, and asses its comparative clinical efficacy in the treatment of Candidiasis patients against liposomal gel, marketed product and hydroethanolic solution of the drug. Drug encapsulated ethosomes and liposomes were prepared and optimized by "Hot" method techni...

Journal: :The Journal of biological chemistry 1993
T Stegmann

Intermediate lipid structures such as inverted micelles and interlamellar attachments, which can form near liquid crystalline lamellar (L alpha) to inverted hexagonal (HII) phase boundaries, are thought to play a role in membrane fusion. To investigate whether these structures are also involved in influenza hemagglutinin-mediated membrane fusion, measurement of fusion under conditions where suc...

2017
Moayad Alhariri Majed A Majrashi Ali H Bahkali Faisal S Almajed Ali O Azghani Mohammad A Khiyami Essam J Alyamani Sameera M Aljohani Majed A Halwani

We investigated the efficacy of liposomal gentamicin formulations of different surface charges against Pseudomonas aeruginosa and Klebsiella oxytoca. The liposomal gentamicin formulations were prepared by the dehydration-rehydration method, and their sizes and zeta potential were measured. Gentamicin encapsulation efficiency inside the liposomal formulations was determined by microbiologic assa...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Corrie Lynn Messerer Euan C Ramsay Dawn Waterhouse Rebecca Ng Eva-Maria Simms Natashia Harasym Paul Tardi Lawrence D Mayer Marcel B Bally

PURPOSE The purpose is to demonstrate whether an appropriately designed liposomal formulation of irinotecan is effective in treating mice with liver-localized colorectal carcinomas. EXPERIMENTAL DESIGN Irinotecan was encapsulated in 1,2-distearoyl-sn-glycero-3-phosphocholine/cholesterol (55:45 molar ratio) liposomes using an ionophore (A23187)-generated transmembrane proton gradient. This for...

2008
Jennifer S. Hong Wyatt N. Vreeland Silvia H. DePaoli Lacerda Laurie E. Locascio Michael Gaitan Srinivasa R. Raghavan

Nanosized gel particles (nanogels) are of interest for a variety of applications, including drug delivery and singlemolecule encapsulation. Here, we employ the cores of nanoscale liposomes as reaction vessels to template the assembly of calcium alginate nanogels. For our experiments, a liposome formulation with a high bilayer melting temperature (Tm) is selected, and sodium alginate is encapsul...

2012
Feng-Yi Yang Ming-Che Teng Maggie Lu Hsiang-Fa Liang Yan-Ru Lee Chueh-Chuan Yen Muh-Lii Liang Tai-Tong Wong

BACKGROUND High-dose tissue-specific delivery of therapeutic agents would be a valuable clinical strategy. We have previously shown that repeated transcranial focused ultrasound is able to increase the delivery of Evans blue significantly into brain tissue. The present study shows that repeated pulsed high-intensity focused ultrasound (HIFU) can be used to deliver high-dose atherosclerotic plaq...

2016
Annabelle Fülöp Denis A. Sammour Katrin Erich Johanna von Gerichten Peter van Hoogevest Roger Sandhoff Carsten Hopf

Phospholipids have excellent biocompatibility and are therefore often used as main components of liposomal drug carriers. In traditional bioanalytics, the in-vivo distribution of liposomal drug carriers is assessed using radiolabeled liposomal constituents. This study presents matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) as an alternative, label-free method ...

Journal: :Langmuir : the ACS journal of surfaces and colloids 2008
Jennifer S Hong Wyatt N Vreeland Silvia H DePaoli Lacerda Laurie E Locascio Michael Gaitan Srinivasa R Raghavan

Nanosized gel particles (nanogels) are of interest for a variety of applications, including drug delivery and single-molecule encapsulation. Here, we employ the cores of nanoscale liposomes as reaction vessels to template the assembly of calcium alginate nanogels. For our experiments, a liposome formulation with a high bilayer melting temperature (Tm) is selected, and sodium alginate is encapsu...

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