Liposarcoma originating in the orbit is extremely rare. Herein, we report a dedifferentiated lipo sarcoma arising from the orbit of a Chinese woman. This patient underwent tumor resection at the age of 56 years and recurred 50 months after the initial resection. Histologically, the initial lesion exhibited features of well-differentiated liposarcoma with focal areas of well-differentiated ossif...

An amelanotic malignant melanoma is characterized by little or no pigment. It is frequently misdiagnosed because it is a rare entity in general, and because of its unusual clinical features. Liposarcoma is one of the most common adult soft tissue sarcomas. We encountered a case of amelanotic melanoma with a concurrent liposarcoma. A 68-year-old man presented with a single, 1.5x1.5 cm round eryt...

BACKGROUND The function of promyelocytic leukemia (PML) bodies is not well known but plays an important role in controlling cell proliferation, apoptosis and senescence. This study was undertaken to analyze the clinical significance of PML body expression in primary tumor samples from malignant fibrous histiocytoma (MFH) and liposarcoma patients. METHODS We studied MFH and liposarcoma samples...

Spermatic cord liposarcoma is a rare medical condition and liposarcomas are most commonly found in the retroperitoneum, in the extremities and less often in the head and the neck area. The spermatic cord is a rare site of origin, accounting for about 3-7% of all liposarcomas. We report a case of liposarcoma of spermatic cord. A 62-year-old male patient presented with a painless right inguinal m...

This is a case of a posterior mediastinal mass in an asymptomatic gentleman, which was resected successfully and he has been disease free for more than a year of follow up. The histopathology findings happen to be a rare occurrence.

Background Liposarcomas (LPS) are rare tumors accounting approximately for 19% of adult soft-tissue tumors [1]. The most recent classification of the WHO divides liposarcomas into 3 main clinicopatological and genetic subtypes: myxoid/round cells liposarcoma, well differentiated / dedifferentiated liposarcoma and pleomorphic liposarcoma [2]. The importance of a total macroscopical resection to ...

Sarcomas are a group of heterogeneous tumours with varying genetic basis. Cytogenetic abnormalities range from distinct genomic rearrangements such as pathognomonic translocation events and common chromosomal amplification or loss, to more complex rearrangements involving multiple chromosomes. The different subtypes of liposarcoma are spread across this spectrum and constitute an interesting tu...

The role of leukotriene (LT) on liver regeneration after hepatectomy is still unknown. LTB4 stagnates in the liver with obstructive jaundice, because LTB4 is excreted in the bile; therefore, LTB4 may have an effect on liver regeneration after hepatectomy with obstructive jaundice. Release of obstructive jaundice and simultaneous 70% hepatectomy was performed in rats to study the effect of 5-lip...

Liposarcoma remains the most common mesenchymal cancer, with a mortality rate of 60% among patients with this disease. To address the present lack of therapeutic options, we embarked upon a study of microRNA (miRNA) expression alterations associated with liposarcomagenesis with the goal of exploiting differentially expressed miRNAs and the gene products they regulate as potential therapeutic ta...

P. Schöffski1, H. Li1, A. Wozniak1, J. Cornillie1, J. Wellens1, T. Van Looy1, D. Hompes2, L. Friedman3, R. Sciot4, M. Debiec-Rychter5 Laboratory of Experimental Oncology, Department of Oncology and Department of General Medical Oncology, KU Leuven and University Hospitals Leuven, Leuven, BELGIUM Department of Surgical Oncology, University Hospitals Leuven, Leuven, BELGIUM Genentech Inc., San Fr...