The plasma lipoproteins and "particles"' fall into four major groups. As defined by paper electrophoresis (3) these are the beta, alpha, and pre-beta lipoproteins, and chylomicrons. The latter two are rich in glyceride and very low in density (< 1.006, Sf > 20). It is now common to reserve the term chylomicrons for the relatively large particles that arise in the gut from exogenous or ingested ...

The key initiating process in atherogenesis is the subendothelial retention of apolipoprotein B-containing lipoproteins. Local biological responses to these retained lipoproteins, including a chronic and maladaptive macrophage- and T-cell-dominated inflammatory response, promote subsequent lesion development. The most effective therapy against atherothrombotic cardiovascular disease to date--lo...

Plasma lipoproteins from patients with familial lecithin:cholesterol acyltransferase (LCAT) deficiency have been fractioned by preparative ultra-centrifugation and gel filtration and their lipid content and reactivity studied. All of the lipoproteins are abnormal with respect to lipid concentration or relative lipid content. The low density lipoproteins (LDL) and high density lipoproteins (HDL)...

INDGREN and co-workers (I) have described L the properties and methodology for the ultracentrifugal study of the entire spectrum of lipoproteins present in human serum. The three most dense lipoproteins described by Lindgren et al. represent the subject of present considerations. These lipoproteins have been identified by their estimated hydrated densities as a lipoprotein of density 1.05 gm/ml...

Bacterial lipoproteins possess diverse structure and functionality, ranging from bacterial physiology to pathogenic processes. As such many lipoproteins, originating from Brucella are exploited as potential vaccines to countermeasure brucellosis infection in the host. These membrane proteins are translocated from the cytoplasm to the cell membrane where they are anchored peripherally by a multi...

This study was designed to gain insight into the role of microsomal triglyceride transfer protein (MTP) in the association of apolipoprotein (apo) B with lipid during intestinal lipoprotein assembly. The MTP-inhibiting compound BMS-200150 (Jamil et al. 1996. Proc. Natl. Acad. Sci. USA 93: 11991-11995) was used to inhibit the lipid transfer activity of MTP in Caco-2 cells. MTP inhibition reduced...

BACKGROUND There is considerable evidence that remnants of triglyceride-rich lipoproteins may be particularly atherogenic. METHODS AND RESULTS Levels of lipoprotein lipids and of apolipoprotein B in low-density lipoproteins were measured in 335 men and women enrolled in a study in which quantitative coronary angiography was carried out at 2-year intervals. Clinical events related to coronary ...

The net synthesis of low density plasma lipoproteins has been shown in the perfused rat liver and in rat liver slices in work reported from this laboratory (2). Haft, Roheim, White, and Eder (3) demonstrated amino acid incorporation into low and high density plasma lipoproteins in the perfused liver, and Radding and Steinberg (4) reported similar observations in rat liver slices. The present ex...