Lipoproteins are large lipid/protein complexes that play a major role in transport of lipids and lipophilic molecules in the plasma and central nervous system (CNS). Plasma lipoproteins represent a dynamic continuum of particles that are constantly undergoing remodulation in their lipid and protein components leading to re-structuring of the particle under normal physiological conditions. The r...

a random block experiment 4×4 with sixteen diets containing four level of protein (35, 40, 45 and 50%) at four carbohydrate to lipid level (1.7, 1.4, .1 and 0.8 ) were designed to research about the ability of utilization of different levels of protein and carbohydrate to lipid ratios diet for juvenile huso huso ( 5.4 ± 0.2, mean sd )in fourteen weeks. fish fed 2-3% of body weight at each day. ...

Microsomal triglyceride transfer protein (MTP) is an endoplasmic reticulum (ER)-resident lipid transfer protein involved in the biosynthesis and lipid loading of apolipoprotein B. MTP was recently suggested to directly regulate the biosynthesis of the MHC I-like, lipid antigen presenting molecule CD1d, based on coprecipitation experiments and lipid loading assays. However, we found that the maj...

Plasma-derived lipid transfer protein (LTP) facilitates the transfer of cholesteryl ester and triglyceride between all lipoproteins. Kinetic models of the transfer event have suggested that transfer is facilitated through the physical interaction (binding) of LTP with its lipoprotein substrate. Such binding has been observed previously between LTP and high density lipoprotein (HDL), but not bet...

Phosphatidylinositol transfer protein (PI-TP) and the non-specific lipid transfer protein (nsL-TP) (identical with sterol carrier protein 2) belong to the large and diverse family of intracellular lipid-binding proteins. Although these two proteins may express a comparable phospholipid transfer activity in vitro, recent studies in yeast and mammalian cells have indicated that they serve complet...

StAR-related lipid transfer domain-3 (STARD3) is a sterol-binding protein that creates endoplasmic reticulum (ER)-endosome contact sites. How this protein, at the crossroad between sterol uptake and synthesis pathways, impacts the intracellular distribution of this lipid was ill-defined. Here, by using in situ cholesterol labeling and quantification, we demonstrated that STARD3 induces choleste...