Substituted phenylazo and phenylazoxy compounds were systematically prepared and their anti-androgenic activity was measured in terms of (1) the growth-inhibiting effect on an androgen-dependent cell line, SC-3, and (2) the binding affinity to nuclear androgen receptor. Generally, azo/azoxy compounds showed cell toxicity, and the growth-inhibiting effects on SC-3 cells correlated with the toxic...

We propose a closed form solution for segmenting mixtures of 2-D translational and 2-D affine motion models directly from the image intensities. Our approach exploits the fact that the spatial-temporal image derivatives generated by a mixture of these motion models must satisfy a bi-homogeneous polynomial called the multibody brightness constancy constraint (MBCC). We show that the degrees of t...

We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.

Yeast cells of five different strains of Paracoccidioides brasiliensis were obtained for partial analysis of lipid composition, and sterol content was determined quantitatively and qualitatively. The determinations were conducted with cells cultured in the presence and absence of amphotericin B and azole derivatives at levels below the MIC.

A number of small molecules, commonly described as autacoids, are extremely important mediators of inflammation. Among the autacoids are a group of lipid mediators called eicosanoids, which are derivatives of the 20-carbon polyunsaturated fatty acid (PUFA), arachidonic acid. Platelet activating factor (PAF), another important lipid mediator of inflammation, is 1-O-alkyl-2(R)-acetylglycero-3-pho...

Introduction The discovery that complex chiral diacetylene derivatives can self-assemble into nanostructures 1 has led to a search for simpler molecules that retain that activity. The search for novel materials is complicated because the factors governing self-assembly are complex and until the simple system is identified the underlying mechanisms are difficult to discover. Unlike spherical lip...

Using site directed mutagenesis we altered an active site residue (Phe107) of the enzyme encoded by fabF3 (SCO3248) in the Streptomyces coelicolor gene cluster required for biosynthesis of the calcium dependent antibiotics (CDAs), successfully generating two novel CDA derivatives comprising truncated (C4) lipid side chains and confirming that fabF3 encodes a KAS-II homologue that is involved in...

When 400 mg/rat/day of secondary autoxidation products of linoleic acid was orally administered 3 times to rats, they died at 30-40 h after the third dose. To search the markers of the toxicity of secondary products in vivo, the rats were killed at 24h after the third dose, and conditions of their digestive tracts and liver were analyzed. In the stomach, macroscopically, inflation, retention of...

New multipotent antioxidants (MPAOs), namely 1,3,4-thiadiazoles and 1,2,4-triazoles bearing the well-known free radical scavenger butylated hydroxytoluene (BHT), were designed and synthesized using an acid-(base-) catalyzed intramolecular dehydrative cyclization reaction of the corresponding 1-acylthiosemicarbazides. The structure-activity relationship (SAR) of the designed antioxidants was per...

The lipid pattern of blood serum has been studied in 32 patients with multiple sclerosis, in whom the disease was either remittent or slowly progressive. Although total lipids, free and esterified cholesterol, aand 0-lipoproteins and chylomicrons were found to be normal in patients, minimal and maximal values showed wider ranges than in controls. Cholesterol esters were slightly reduced (71,6 ±...