The Rothmund–Thomson syndrome (RTS) is a rare autosomal recessive disease associated with poikiloderma, telangiectasias, sun-sensitive rash, hair growth problems, juvenile cataracts and, for subset of some RTS patients, high risk cancer, especially osteosarcoma. Most the cases are caused by biallelic mutations RECQL4 gene, coding DNA helicase that belongs to RecQ family. Cellular and post-radio...

: Wilson disease (WD) is an autosomal recessive with copper overload. Its clinical picture depends on specific tissue/system damage by the excess copper.

heredity hearing loss (hl) is the most prevalent sensory disorder and most cases are non-syndromic. eighty percent of non-syndromic sensorineural deaf patients show an autosomal recessive pattern of inheritance. to date, 47 genes and 98 loci have been reported for this mode of inheritance. previous studies in our center showed the high prevalence of dfnb3 among iranian deaf families. pjvk (dfnb...

this study aimed to investigate the contribution of four common dfnb (“dfn” for deafness and “b” for autosomal resessive locus) loci and gjb2 gene mutations (exon 2) in hearing impairment in individuals living in markazi and qom provinces of iran. forty consanguineous iranian families with at least three affected individuals in family or pedigree who suffer from an autosomal recessive non-syndr...

idiopathic hypogonadotropic hypogonadism (ihh) is a condition caused by low doses of hypothalamic gonadotropin-releasing hormone (gnrh) leading to absence or incomplete sexual maturation. one of the disorders leading to ihh is kallmann syndrome which is characterized by gnrh deficiency with anosmia or hyposmia. this disorder generally occurs as a hereditary syndrome with x-linked recessive inhe...

in this paper, we consider a cooperative cognitive radio network in which there is an ofdm primary link and multiple single carrier secondary links.the primary link is required to maintain its secrecy rate above a predefined threshold. if the secrecy rate requirement is not satisfied, the secondary system help primary link to maintain its secrecy rate requirement. in doing so, the secondary trans...

in this paper, we present a binary-linear optimization model to prevent the spread of an infectious disease in a community. the model is based on the remotion of some connections in a contact network in order to separate infected nodes from the others. by using this model we nd an exact optimal solution and determine not only the minimum number of deleted links but also their exact positions. ...

seistan was one of the important ancient urban centres in south eastern persia. the ruins of the city show the prosperity and fertility of this city to the extent that a british civil officer considered it as the ancient london of asia. this article attempts to describe the enormous latent wealth of this ancient city which made it important for strategic, political and commercial reasons. due t...