The ability to detect and quantify macrophage accumulation can provide important diagnostic and prognostic information for atherosclerotic plaque. We have previously shown that LyP-1, a cyclic 9-amino acid peptide, binds to p32 proteins on activated macrophages, facilitating the visualization of atherosclerotic plaque with PET. Yet, the in vivo plaque accumulation of monomeric [(18)F]FBA-LyP-1 ...

Thermodynamic perturbation theory is applied to the model of globular proteins studied by ten Wolde and Frenkel [P. R. ten Wolde and D. Frenkel Science 77, 1975 (1997)] using computer simulation. It is found that the reported phase diagrams are accurately reproduced. The calculations show how the phase diagram can be tuned as a function of the length scale of the potential.

At the distance of NGC 5128 (3.6±0.2 Mpc) it is possible to resolve globular clusters with high resolution imaging from the ground, thus allowing the globular cluster candidate selection primarily through their morphological properties. I report the discovery of 71 globular clusters in NGC 5128 on VLT UT1+FORS1 images, including the faintest members (MV ∼ −5) known to date in this galaxy as wel...

A new class of high molecular weight polysulfated PEO dendrimer-like glycopolymer has been synthesized by a combination of arm-first and core-first methodologies followed by trichloroacetimidate glycosidation as a facile bioconjugation strategy. An L-selectin antagonist was identified that exhibits 103-fold greater activity than other multivalent sLex glycopolymers and 20-50 times greater poten...

Understanding the structure of hybrid nanoparticle-lipid multilayers is fundamental importance to their bioanalytical applications and nanotoxicity, where nanoparticle-membrane interactions play an important role. Poly(amidoamine) (PAMAM) dendrimers are branched polymeric nanoparticles with potential biomedical due precise tunability physicochemical properties. Here, effect PAMAM (2.9–4.5 nm) e...

in this study, a novel solid dendrimer amine (hyperbranched polymers) was prepared using mesoporous carbon nitride functionalized by melamine based dendrimer amines. this adsorbent was denoted mda-mcn-1. the process was stepwise synthesis and hard-templating method using mesoporous silica sba-15 as a template. cyanuric chloride and n,n-diisopropylethylamine (dipea, merck) were used for function...

The spread of antibiotic resistant bacteria is one of the most pressing problems in human health today. In the case of the opportunistic pathogen Pseudomonas aeruginosa, which causes lethal airway infections in cystic fibrosis and immunocompromised patients, the formation of biofilms plays an important role in antibiotic resistance and disease progression. Biofilm formation is mediated in part ...

We investigate diffusion on models of large molecules with dendrimer structure. The models we use are topological Cayley trees. We focus on diffusion properties, such as the excursion distance, the mean square displacement of the diffusing particles, and the area probed, as given by the random walk parameter SN , the number of the distinct sites visited. Finally we look at the trapping kinetics...

Electrospray ionization tandem mass spectrometry (ESI-MS/MS) was used to probe the binding of silver ions and reduced silver species with polyamidoamine generation 1 amine-terminated (PAMAMG1NH2) and generation 2 hydroxyl-terminated (PAMAMG2OH) dendrimers. At Ag(+)/PAMAMG2OH molar ratios of 1, 2:1 and low abundance 3:1 complexes emerge. Similar...