Proteins tagged with lysine (Lys, K) 48 polyubiquitins chains are destined for degradation by the 26S proteasomal system. Impairment of the ubiquitin proteasome system (UPS) function culminates in the accumulation of polyubiquitinated proteins in many neurodegenerative conditions including Parkinson's disease (PD). Nevertheless, the cellular mechanisms underlying cell death induced by an impair...

Background According to epidemiological studies, about 2-4% of the population in industrialized countries suffer from food allergies. The symptoms can range from minor skin rash to life threatening anaphylaxis and at present no effective therapy is available. Strict avoidance of the offending food is therefore mandatory for allergic individuals. Nut allergens are regarded highly problematic, be...

What is CNSL? Cashew nut Shell Liquid (CNSL) is a reddish brown viscous liquid, having the honeycomb structure of the shell of cashew nut obtained from cashew tree. Botanical name of Cashew: Anacardium occidentale L CAS number: 8007-24-7 Area of growth of Cashew tree Coastal areas of Asia and Africa. Mozambique, India, Vietnam and Brazil Specification of Cashew nut shell The shell is about 0.3 ...

The article studies the most evident examples of fast growing business from start-ups to companies – unicorns, analyzes causes their quick success and shows key trends future start-ups. authors identify realizing among which technological start-ups, fintech in field transport, EdTech, medical e-commerce. review successful companies-unicorns new decade 21st century. They analyze different lines ...

This study compared the biomechanics of 3 fixation techniques: bilateral pedicle screw (BPS) fixation, unilateral pedicle screw (UPS) fixation, and UPS supplemented with translaminar facet screw (UPS+TLFS) fixation. The study was conducted in an L3-L5 finite element model. Three different finite element models were created by adopting different fixation techniques after removal of the left L3-L...

Ubiquitin proteasome system (UPS) impairment and iron misregulation have been implicated in dopamine (DA) neuron degeneration in Parkinson's disease. As previously shown, proteasome inhibition in a rodent model can cause nigral neuron degeneration accompanied by iron accumulation. To investigate the involvement of iron in DA neuron degeneration, we generated an in vitro model by applying protea...

After a decade of widespread attention for the entrepreneurial efforts of individuals, the focus seems to partly shift to companies and their contribution to new firm formation. Splitting new firm formation in a birth rate for spin-offs and one for start-ups, allows a structural and comparative analysis of regions and their spin-off activities. In the Netherlands, the Chamber of Commerce has de...