نتایج جستجو برای: limited cutaneous scleroderma
تعداد نتایج: 485654 فیلتر نتایج به سال:
The utility of allogeneic hematopoietic stem cell transplantation is limited by graft-versus-host disease (GVHD), a significant cause of morbidity and mortality. Patients with GVHD exhibit cutaneous manifestations with histological features of interface dermatitis followed by scleroderma-like changes. JAK inhibitors represent a class of immunomodulatory drugs that inhibit signaling by multiple ...
BACKGROUND Studies on gastrointestinal symptoms, dysfunctions, and neurological disorders in systemic scleroderma are lacking so far. METHODS Thirty-eight scleroderma patients (34 limited, 4 diffuse), 60 healthy controls and 68 dyspeptic controls were scored for upper and lower gastrointestinal symptoms (dyspepsia, bowel habits), gastric and gallbladder emptying to liquid meal (functional ult...
OBJECTIVE To evaluate in a large group of scleroderma patients, the association of nailfold videocapillaroscopic patterns with both demographic and clinical features. METHODS One hundred and three Italian patients (91 women and 12 men, mean age 54.3 years, median disease duration 7 yrs, 68 with limited and 35 with diffuse subset of disease), consecutively enrolled for the study, underwent nai...
BACKGROUND Systemic sclerosis (scleroderma; SSc) is an orphan disease with the highest case-specific mortality of any connective-tissue disease. Excessive collagen deposit in affected tissues is a key for the disease's pathogenesis and comprises most of the clinical manifestations. Lidocaine seems to be an alternative treatment for scleroderma considering that: a) the patient's having excessive...
Raynaud’s phenomenon (RP) is one of the early clinical manifestations of diffuse connective tissue diseases (DCTD), such as systemic sclerosis (SSc), mixed connective tissue disease (MCTD), systemic lupus erythematosus (SLE), and dermatomyositis (DM)/ polymyositis (PM), and nailfold capillaroscopy (NC) enables an in vivo assessment of the morphology of cutaneous capillaries, and has been used f...
Background: Interstitial lung disease (ILD) is the leading cause of death in scleroderma (SSc) with decline FVC as a predictor mortality patients SSc-ILD, especially early course disease. Objectives: The aim this study to determine survival rate SSc-ILD Malaysian cohort from University Malaya Medical Centre (UMMC). Methods: 61 clinically diagnosed were identified and prospectively recruited. Ba...
More than 300 sera from patients with a connective tissue disease were analyzed with the immunoblotting technique. The presence of autoantibodies against an 86,000-mol wt marker antigen for diffuse scleroderma (Scl-86) was found in 14 out of 33 patients with scleroderma. The presence of anti-Scl-86 antibodies seemed to correlate with the diagnosis of diffuse scleroderma since they were found in...
OBJECTIVES Pulmonary fibrosis is a leading cause of death in systemic sclerosis (SSc). This report examines the differences at baseline and over 12 months between patients with limited versus diffuse cutaneous SSc who participated in the Scleroderma Lung Study. METHODS SSc patients (64 limited; 94 diffuse) exhibiting dyspnoea on exertion, restrictive pulmonary function and evidence of alveoli...
HSV: herpes simplex virus SCC: squamous cell carcinoma INTRODUCTION Metastatic disease to the skin can be difficult to diagnose clinically because it often mimics many infectious, inflammatory, and neoplastic skin conditions. Cutaneousmetastases can present as dermal or subcutaneous nodules, exophytic tumors resembling melanoma or nonmelanoma skin cancer, erythematous patches and plaques resemb...
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