The intricate interactions that regulate relationships between endogenous tissue cells and infiltrating immune cells in the rheumatic joint, particularly in rheumatoid arthritis (RA), were the subject of the meeting. A better understanding of these interactions might help to define intervention points that could be used to develop specific therapies. The presentations and discussions highlighte...

Meniscal tears are a common cause of stifle lameness in dogs. Use of autologous synoviocytes from the affected stifle is an attractive cell source for tissue engineering replacement fibrocartilage. However, the diseased state of these cells may impede in vitro fibrocartilage formation. Synoviocytes from 12 osteoarthritic ("oaTSB") and 6 normal joints ("nTSB") were cultured as tensioned bioscaff...

Casticin, as a major effective component in Chinese herbal medicine Vitex agnus-castus exhibits an antiinflammatory property to rheumatoid arthritis (RA), while the potential mechanism is unclear. We aim at investigating the mechanism of Casticin on lipopolysaccharides (LPS)-induced fibroblast-like synoviocytes (LiFLSs) inflammation model. Fibroblast-like synoviocytes (FLSs) were treated with 2...