Introduction: Our previous study has showed that chronic administration of magnesium oxide nanoparticles (MgO NP) can reduce anxiety in adult male rat. In this study the effects of MgO NP on anxiety induced by morphine withdrawal were investigated in adult male mice. Methods: Adult male NMRI mice (weighing 27 ± 3 g) divided into groups: control, receiving intraperitoneal (i.p.) injection...

depression is a heterogenous, multifaceted disorder with symptoms manifested at the psychological, behavioral and physiological level. therefore, present study was designed as a model to analyze the long lasting effects of methylmercury chloride in male rats with a focus on depression like behavior. male albino rats of wistar strain were exposed orally to a dose of 2 mg/kg of methylmercury chlo...

Methamphetamine (MA), a highly addictive psychostimulant, produces long-lasting neurotoxic effects well proven in nigrostriatal dopaminergic neurons. Considering the similarities between pathological profile of MA neurotoxicity and Parkinson's disease (PD), some reports show that previous MA abusers will be at greater risk of PD-like motor deficits. To answer the question if repeated MA exposur...

Depression is a heterogenous, multifaceted disorder with symptoms manifested at the psychological, behavioral and physiological level. Therefore, present study was designed as a model to analyze the long lasting effects of methylmercury chloride in male rats with a focus on depression like behavior. Male albino rats of Wistar strain were exposed orally to a dose of 2 mg/kg of methylmercury chlo...

Objective(s): Cerebral ischemia/reperfusion (I/R) causes brain inflammation that ultimately causes long time brain function disturbances. We aimed to evaluate the effect of ellagic acid (EA) on anxiety, depression, locomotion behaviors, blood-brain barrier (BBB) permeability, brain edema, and inflammation in male rats with cerebral I/R. Materials and ...