Introduction: Bone metastases are common in the progression of various tumors leading to severe pain and decrease in quality of life. The aim of this study was to optimize the production of 68Ga-BPAMD as an ideal bone imaging agent using an in-house 68Ge/68Ga generator for future clinical use. Methods: The optimized condit...

Ion pair dispersive liquid- liquid microextraction (IP-DLLME) method combined with flame atomic absorption spectrometry was proposed for the determination of trace amounts of copper(II). By using pyrocatechol violet as chelating agent and cetyltrimethyl ammonium bromide as an ion pairing agent, the trace amount of copper(II) was extracted in chloroform. The factors influencing the formation cop...

Some new symmetrical tetraaza Schiff base ligands containing 2-quinolinecarboxaldehyde moiety formed from condensation reaction of 2-quinolinecarboxaldehyde and o-phenylenediamine derivatives, such as N, Nˊ-bis(2-quinolylmethylidene)-4-methoxy-1, 2-phenylenediimine (L1), N, Nˊ-bis(2-quinolylmethylidene)-4-methy-1, 2-phenylenediimine (L2), N, Nˊ-bis(2-quinolylmethylidene)-4-chloro-1, 2-phenylene...

The efficacy of activation methods and coupling were studied in the context of performance in batch and fixed bed binding experiments utilizing cell culture fluids or blood plasma as feedstock. Conclusions were drawn regarding selection of solid phase according to pore size, rigidity, pH stability, Chemistry of derivation and activation, and gross concentration of immobilized ligand require...

Lithium trimethylsilyldiazomethanide and a cobalt (II) precursor with an N-anchored tris-NHC (TIMENmes ) ligand provide access to the nitrilimide 1. Complex 1 was structurally characterized by single-crystal X-ray diffractometry (SC-XRD) its electronic structure examined in detail, including EPR spectroscopy, SQUID magnetometry computational analyses. The desilylation of C-(trimethylsilyl)nitri...

The phenomenon of molecular binding, where two molecules, referred to as a receptor and ligand, bind together form ligand-receptor complex, is ubiquitous in biology essential for the accurate functioning all life-sustaining processes. probability single forming complex with any one L surrounding ligand molecules at thermal equilibrium can be derived from partition function obtained Gibbs-Boltzm...

The purpose of the present research work is prediction of electronic and physico-chemical properties of the novel medicinal compound Ticagrelor (AZD6140) using density functional theory (DFT) method. Firstly, its molecular structure was optimized at B3LYP/6-311++G(d,p) basis set of theory at room temperature. The global reactivity indices used to study the reactivity and stability of the title ...

The interaction between hydronium ion and several crown ethers was studied via conductometry in nitromethane at 25 °C and 1H-NMR techniques. The stabilities of the resulting 1:1 complexes were determined from the conductance data and found to vary in the order DC18C6 > 18C6 > DB30C10 > DB24C8 > DB18C6 > ~B15C5 > DB21C7. For the first time, evidences for the formation of a 2:1 san...

in this study at first , an azo dye, 2,7- naphthalenediol, 2-[(4-bromophenyl)azo (bpand) as a ligand has been synthesized by addition of p-bromoaniline to the modified montomorillonite k10 clay. this ligand was characterized using 1h-nmr, uv-vis and ir spectroscopies. subsequently, its interaction with calf thymus deoxyribonucleicacid ,ct-dna was investigated in 5 mm phosphate buffer solution, ...