نتایج جستجو برای: lifespan

تعداد نتایج: 15331  

Journal: :Journal of cell science 1987
Y Takagi T Nobuoka M Doi

Paramecia cells, like human diploid cells cultured in vitro, provide a useful model system for understanding the mechanism that limits division potential. The reported maxima of the clonal lifespan of Paramecium tetraurelia fall into two ranges: from 220 to 258 fissions and from 310 to 325 fissions. We found that neither the selection of vigorous lines nor the cryptic occurrence of autogamy off...

2015
Devon Chandler-Brown Haeri Choi Shirley Park Billie R. Ocampo Shiwen Chen Anna Le George L. Sutphin Lara S. Shamieh Erica D. Smith Matt Kaeberlein

The response to osmotic stress is a highly conserved process for adapting to changing environmental conditions. Prior studies have shown that hyperosmolarity by addition of sorbitol to the growth medium is sufficient to increase both chronological and replicative lifespan in the budding yeast, Saccharomyces cerevisiae. Here we report a similar phenomenon in the nematode Caenorhabditis elegans. ...

2018
Dylan Henderson Christian Huebner Moses Markowitz Nicole Taube Zachary M. Harvanek Ursula Jakob Daniela Knoefler

Lifespan in poikilothermic organisms, such as Caenorhabditis elegans, can be substantially increased simply by decreasing growth temperature. To gain insights into the mechanistic underpinnings of this effect, we investigated the effects of temperature in development and adulthood on C. elegans lifespan. We found that worms exposed to 25°C during development and shifted to 15°C in adulthood exh...

2017
Nathan G Skene Marcia Roy Seth Gn Grant

The genetic mechanisms regulating the brain and behaviour across the lifespan are poorly understood. We found that lifespan transcriptome trajectories describe a calendar of gene regulatory events in the brain of humans and mice. Transcriptome trajectories defined a sequence of gene expression changes in neuronal, glial and endothelial cell-types, which enabled prediction of age from tissue sam...

Journal: :Mechanisms of ageing and development 2005
Glenda Walker Koen Houthoofd Jacques R Vanfleteren David Gems

The nematode Caenorhabditis elegans has been subjected to dietary restriction (DR) by a number of means, with varying results in terms of fecundity and lifespan. Two possible mechanisms by which DR increases lifespan are reduction of metabolic rate and reduction of insulin/IGF-1 signalling. Experimental tests have not supported either possibility. However, interaction studies suggest that DR an...

2014
Christoph Ruckenstuhl Christine Netzberger Iryna Entfellner Didac Carmona-Gutierrez Thomas Kickenweiz Slaven Stekovic Christina Gleixner Christian Schmid Lisa Klug Alice G. Sorgo Tobias Eisenberg Sabrina Büttner Guillermo Mariño Rafal Koziel Pidder Jansen-Dürr Kai-Uwe Fröhlich Guido Kroemer Frank Madeo

Reduced supply of the amino acid methionine increases longevity across species through an as yet elusive mechanism. Here, we report that methionine restriction (MetR) extends yeast chronological lifespan in an autophagy-dependent manner. Single deletion of several genes essential for autophagy (ATG5, ATG7 or ATG8) fully abolished the longevity-enhancing capacity of MetR. While pharmacological o...

Journal: :Annual review of psychology 1999
P B Baltes U M Staudinger U Lindenberger

The focus of this review is on theory and research of lifespan (lifespan developmental) psychology. The theoretical analysis integrates evolutionary and ontogenetic perspectives on cultural and human development across several levels of analysis. Specific predictions are advanced dealing with the general architecture of lifespan ontogeny, including its directionality and age-differential alloca...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
N R Austriaco L P Guarente

Budding yeast cells divide asymmetrically, giving rise to a mother and its daughter. Mother cells have a limited division potential, called their lifespan, which ends in proliferation-arrest and lysis. In this report we mutate telomerase in Saccharomyces cerevisiae to shorten telomeres and show that, rather than shortening lifespan, this leads to a significant extension in lifespan. This extens...

2016
Peter K Joshi Krista Fischer Katharina E Schraut Harry Campbell Tõnu Esko James F Wilson

Lifespan is a trait of enormous personal interest. Research into the biological basis of human lifespan, however, is hampered by the long time to death. Using a novel approach of regressing (272,081) parental lifespans beyond age 40 years on participant genotype in a new large data set (UK Biobank), we here show that common variants near the apolipoprotein E and nicotinic acetylcholine receptor...

2018
Shuhei Nakamura Tamotsu Yoshimori

Autophagy is an evolutionally conserved cytoplasmic degradation system in which varieties of materials are sequestered by a double membrane structure, autophagosome, and delivered to the lysosomes for the degradation. Due to the wide varieties of targets, autophagic activity is essential for cellular homeostasis. Recent genetic evidence indicates that autophagy has a crucial role in the regulat...

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