Recently, it has become apparent that surface proteins commonly transfer between immune cells in contact. Inhibitory receptors and ligands exchange between cells during NK cell surveillance and we report here that NK cells also acquire activating ligands from target cells. Specifically, the stress-inducible activating ligand for NKG2D, MHC class I-related chain A (MICA), transferred to NK cells...

MICA is a scalable in-memory key-value store that handles 65.6 to 76.9 million key-value operations per second using a single general-purpose multi-core system. MICA is over 4–13.5x faster than current state-of-the-art systems, while providing consistently high throughput over a variety of mixed read and write workloads. MICA takes a holistic approach that encompasses all aspects of request han...

Human cytomegalovirus (HCMV) evades T-cell recognition by down-regulating expression of major histocompatibility complex (MHC) class I and II molecules on the surfaces of infected cells. Contrary to the "missing-self" hypothesis, HCMV-infected cells are refractory to lysis by natural killer (NK) cells. Inhibition of NK cell function is mediated by a number of HCMV immune evasion molecules, whic...

OBJECTIVE Recent studies have demonstrated that MICA (major histocompatibility complex class I chain-related genes) on the short arm of the chromosome 6 are associated with susceptibility to various autoimmune diseases in Caucasians. The aim of our study was to investigate the role of MICA in type 1 diabetes susceptibility independent of the HLA DR-DQ polymorphism in genetically distinct Korean...

Extended layering of ionic liquids (ILs) on the mica surface has been reported by several groups previously and it is generally accepted that the electrostatic interaction at the IL/mica interface is critical to the observed extended layering. Here we report that, indeed, water adsorption on the mica surface is the key to the extended layering of ionic liquids. The atomic force microscopy (AFM)...

This study investigated whether polymorphisms of the MICA (major histocompatibility complex class I chain-related gene A) gene are associated with eye lesions due to Toxoplasma gondii infection in a group of immunocompetent patients from southeastern Brazil. The study enrolled 297 patients with serological diagnosis of toxoplasmosis. Participants were classified into two distinct groups after c...

MICA and MICB are stress-induced ligands recognized by the activating receptor NKG2D. A microRNA encoded by human cytomegalovirus downregulates MICB expression by targeting a specific site in the MICB 3¢ untranslated region. As this site is conserved among different MICB alleles and a similar site exists in the MICA 3¢ untranslated region, we speculated that these sites are targeted by cellular...

MHC class I-related chain molecules A and B (MICA and B) expressed on the cell-surface of tumor cells are ligands for an activating receptor, NKG2D, expressed on natural killer (NK) cells and stimulate the NK cell-mediated cytotoxicity. On the other hand, the soluble form of MICA and B produced by proteolytic cleavage of cell-surface MIC interferes with NK cell-mediated cytotoxicity. We investi...

Surface-enhanced Raman scattering (SERS) and surface-enhanced resonance Raman scattering (SERRS) results are reported for self-assembled monolayers (SAMs) of 4-(4-mercaptobutyl)-4‘-ferrocenylazobenzene, compound 1, on Admica and Wmica thin films. Two different Admica surfaces, designated Au(rough)/ mica and Au(lll)/mica, have been characterized by atomic force microscopy (AFM) to define their r...