Jockusch showed that 2-generic degrees are downward dense below a 2-generic degree, but in the case of 1-generic degrees Kumabe, and independently Chong and Downey constructed a minimal degree computable from a 1-generic degree. We explore the tightness of these results. We solve a question of Barmpalias and Lewis-Pye by constructing a minimal degree computable from a weakly 2-generic one. The ...

The Wistar-Kyoto (WKY) rat shows marked susceptibility to crescentic glomerulonephritis. In the model of nephrotoxic nephritis (NTN) that is induced by a small dose of nephrotoxic globulin, WKY rats developed crescents in 80 +/- 2% of glomeruli at day 10, whereas no crescents were seen in Lewis rats. This was associated with marked increase in monocyte chemoattractant protein-1 synthesis in WKY...

Carbohydrates in various forms play vital roles in numerous critical biological processes including cell-cell adhesion and communication, embryo development, immune response, etc. Fluorescent sensors for such carbohydrates have a wide range of potential applications including glucose concentration determination, cell labeling and targeting based on carbohydrate biomarkers, as in vitro diagnosti...

Abstract The affine matrix-ball construction (abbreviated AMBC) was developed by Chmutov, Lewis, Pylyavskyy, and Yudovina as an generalization of the Robinson–Schensted correspondence. We show that AMBC gives a simple way to compute distinguished involution in each Kazhdan–Lusztig cell symmetric group. then use give 1st known canonical presentation for asymptotic Hecke algebras extended groups....

The selectins (lectin-EGF-complement binding-cell adhesion molecules [LEC-CAMs]) are a family of mammalian receptors implicated in the initial interactions between leukocytes and vascular endothelia, leading to lymphocyte homing, platelet binding, and neutrophil extravasation. The three known selectins, L-selectin (leukocyte adhesion molecule-1 [LECAM-1]), E-selectin (endothelial-leukocyte adhe...

Prolonged hypothermic storage causes ischemia-reperfusion injury (IRI) in the renal graft, which is considered to contribute to the occurrence of the delayed graft function (DGF) and chronic graft failure. Strategies are required to protect the graft and to prolong renal graft survival. We demonstrated that xenon exposure to human proximal tubular cells (HK-2) led to activation of range of prot...

OBJECTIVES Lung cancer is associated with a significant rate of locoregional recurrence after surgical resection, particularly when nonanatomic wedge resections are performed. The primary aim of this study was to assess the feasibility of a microsphere drug delivery system to locally deliver chemotherapy and prevent the establishment and growth of lung cancer cells and establish proof of concep...

It has previously been reported that synthetic peptides corresponding to sequences derived from T-cell receptor variable regions identified as dominant in the T-cell-mediated autoimmune disease experimental allergic encephalomyelitis in both the mouse and the rat can down-regulate disease in Lewis rats. In contrast to these results, we have found that immunization of Lewis rats with such peptid...

The Lewis lung carcinoma is a transplantable metastatic tumor of the C57BL mouse strain. When cells derived from this tumor are inoculated onto the chorioallantoic membrane (CAM) of 9- to 11-day-old chick embryos, large tumors are produced. Although most of these tumors contain mouse cells, they can no longer be transplanted either in C57BL mice or on the CAM. Cloned cells obtained from Lewis l...