In this paper we propose an automated method for Levodopa-induced dyskinesia (LID) detection and classification of its severity. The method is based on the analysis of the signals recorded from accelerometers which are placed on certain positions on the patient’s body. The signals are analyzed using a moving window and several features are extracted. Based on these features a decision tree is u...

The R2 response on the blink reflex was found to be abnormal in seven out of 17 Huntington's disease descendants. Such abnormalities were present in four untreated subjects and in three further subjects after administration of a single oral dose of levodopa-carbidopa. An increase in latency and differential latency (four cases), or in a single one of these parameters (three cases) were the abno...

Synaptic dopamine (DA) release induced by amphetamine or other Rationale: experimental manipulations can displace [ C]raclopride (RAC*) from dopamine D2-like receptors. We hypothesized that exogenous levodopa might increase dopamine release at striatal synapses under some conditions but not others, allowing a more naturalistic assessment of presynaptic dopaminergic function. Presynaptic dopamin...

Synaptic dopamine (DA) release induced by amphetamine or other Rationale: experimental manipulations can displace [ C]raclopride (RAC*) from dopamine D2-like receptors. We hypothesized that exogenous levodopa might increase dopamine release at striatal synapses under some conditions but not others, allowing a more naturalistic assessment of presynaptic dopaminergic function. Presynaptic dopamin...

Background In patients with Parkinson's disease (PD), oral dosing of extended-release carbidopa-levodopa (Rytary, IPX066 [ER CD-LD]) achieves peak levodopa plasma concentrations within 1 hour and maintains them for 4-6 hours. Aims To compare the onset and duration of ER CD-LD benefit with those of immediate-release carbidopa-levodopa (IR CD-LD) in PD patients with motor fluctuations, using cr...

BACKGROUND Levodopa remains the most effective drug for the treatment of Parkinson's disease (PD). However, long-term levodopa treatment is associated with the emergence of levodopa-induced dyskinesia (LID), which has hampered its use for PD treatment. The mechanisms of LID are only partially understood. A previous study showed that KN-93, a Ca(2+)/calmodulin-dependent protein kinase II (CaMKII...

Smith, Jill L., Jeong-Sun Ju, Bithika M. Saha, Brad A. Racette, and Jonathan S. Fisher. Levodopa with carbidopa diminishes glycogen concentration, glycogen synthase activity, and insulin-stimulated glucose transport in rat skeletal muscle. J Appl Physiol 97: 2339–2346, 2004; doi:10.1152/japplphysiol.01219.2003.—We hypothesized that levodopa with carbidopa, a common therapy for patients with Par...

Dopaminergic signalling in the striatum contributes to reinforcement of actions and motivational enhancement of motor vigour. Parkinson's disease leads to progressive dopaminergic denervation of the striatum, impairing the function of cortico-basal ganglia networks. While levodopa therapy alleviates basal ganglia dysfunction in Parkinson's disease, it often elicits involuntary movements, referr...

BACKGROUND Recent studies have shown that expression of G protein-coupled receptor kinase 6 (GRK6) and β-arrestin1 in the striatum is closely associated with hyperactive dopamine receptors in rats with levodopa-induced dyskinesia (LID). Our research group has shown that Tianqi antitremor granules have a significant effect on the motor complications of Parkinson's disease (PD). However, whether ...

Dopaminergic signalling in the striatum contributes to reinforcement of actions and motivational enhancement of motor vigour. Parkinson’s disease leads to progressive dopaminergic denervation of the striatum, impairing the function of cortico-basal ganglia networks. While levodopa therapy alleviates basal ganglia dysfunction in Parkinson’s disease, it often elicits involuntary movements, referr...