The infiltration of inflamed tissues by leukocytes is a key event in the development and progression of inflammation. Although individual cytokines, which coordinate extravasation, have become the targets for therapy, a mechanism that is common to white cell extravasation, regardless of the specific molecular mechanism involved, would represent a more attractive therapeutic target. Such a targe...

Kidney allograft rejection is associated with infiltration of inflammatory CD11b+ leukocytes. A CD11b agonist leukadherin-1 (LA1) increases leukocyte adhesion, preventing their transmigration and tissue recruitment in vivo. Here, we test the extent to which LA1-mediated activation of CD11b/CD18 enhances kidney allograft survival in a mouse model of fully MHC-mismatched orthotopic kidney transpl...

The tight junction proteins (TJPs) are major determinants of endothelial cells comprising physiological vascular barriers such as the blood-brain barrier, but little is known about their expression and role in immune cells. In this study we assessed TJP expression in human leukocyte subsets, their induction by immune activation and modulation associated with autoimmune disease states and therap...

Plasma C1 inhibitor (C1INH) is a natural inhibitor of complement and contact system proteases. Heterozygosity for C1INH deficiency results in hereditary angioedema, which is mediated by bradykinin. Treatment with plasma C1INH is effective not only in patients with hereditary angioedema, but also in a variety of other disease models, in which such therapy is accompanied by diminished neutrophil ...

BACKGROUND Clostridium novyi-NT (CNV-NT), has shown promise as a bacterolytic therapy for solid tumors in mouse models and in dogs with naturally developing neoplasia. Factors that impact the immunologic response to therapy are largely unknown. The goal of this pilot study was to determine if plasma immune biomarkers, immune cell function, peripheral blood cytological composition and tumor char...

OBJECTIVE To determine the frequency and severity of leucopenia during antiviral treatment in patients with hepatitis C and the effectiveness of G-CSF (Granulocyte-Colony Stimulating Factor) in its management. STUDY DESIGN An observational study. PLACE AND DURATION OF STUDY Shafi Clinic, Rawalpindi, from July 2005 to July 2007. METHODOLOGY Patients with Polymerase Chain Reaction (PCR) pos...

Long-term outcomes of perinatal exposure to maternal antiretroviral therapy in HIV-exposed uninfected (HEU) children are unknown. However, both HIV antiretroviral therapy and autism spectrum disorder (ASD) have been associated with mitochondrial alterations. Leukocyte mitochondrial DNA (mtDNA) content can serve as a marker for mitochondrial dysfunction. In this cross-sectional, nested case-cont...

in this study morphological characterization of leukocyte and erythrocyte were investigated in central asian tortoise (testudo horsfieldii) in iran. 7 males and 7 females were used in this study. erythrocyte and leukocyte morphology were described using wright´s technique. the sizes of erythrocyte and their nuclei were measured using an ocular micrometer under objective lenses (100x). results o...

background: the study aimed to examine the association between human leukocyte antigen (hla) class ii allele frequencies and breast cancer in iranian women. methods: a total of 100 patients with pathologically proven breast cancer who referred to cancer institute were randomly selected and compared with a group of age matched healthy blood donors (n = 80). hla class ii alleles were determined b...

conclusions respiratory distress is more common in eos whereas jaundice, fever and seizure are more likely to be observed in los infants. considering the results, clinical manifestations should be regarded as an important part of early diagnosis of sepsis. objectives the aim of this study was to evaluate, record and rank the clinical manifestations and lab data of neonates with clinical sepsis....