Down syndrome [DS] is the most common chromosomal disorder in population manifested by intellectual disabilities of varying degrees, often accompanied disorders organ systems. Compared to children without DS, these have a greater risk developing malignancy such as acute leukemia. Leukemia blood cells and lymph nodes form cancer children. Its treatment with DS more complex compared this syndrome...

We report bilateral proptosis as the unusual initial presentation of juvenile myelomonocytic leukemia in a Ugandan child. Juvenile was diagnosed with complete blood count and bone marrow aspiration biopsy. This is first description orbital involvement occurring setting leukemia, despite leukemic infiltration relatively common middle East, Asia, Africa. In general, simultaneous neoplastic both o...

Scurvy is a nondiscriminatory disease process resulting from nutritional deficiency of ascorbic acid (vitamin C). Identifying scurvy can be demanding due to the perceived rarity condition, and it become tricky diagnostic question given variety nonspecific symptoms, including skeletal other systems affected. Diffuse musculoskeletal pain in children with no specific cause usually fugue. Different...

abstract   background : leukemia is one of the mostcommon cancers in children, comprising more than a third of all childhood cancers. newly affected patients in usa are estimated as 10100cases, and if these cases are diagnosed late or proper treatment is not applied, then it can be mortal. because rapid and proper diagnosis of leukemia based on clinical or medicinal findings (without biopsy) is...

Clinically significant myocardial infiltration by blast cells is a rare occurrence in acute leukemia. Heart failure rate children with hemato-oncological diseases unknown. Here we report clinical case of an 8-year-old female patient B-cell lymphoblastic leukemia as well heart that resolved during specific therapy for the cancer. The patient's parents gave consent to use their child's data, incl...

Children with Down syndrome have an increased risk for developing both acute myeloid as well as lymphoblastic leukemia. These leukemias differ in presenting characteristics and underlying biology when compared with leukemias occurring in non-Down syndrome children. Myeloid leukemia in children with Down syndrome is preceded by a preleukemic clone (transient leukemia or transient myeloproliferat...

BACKGROUND Children with Down syndrome have unique immune profiles and increased leukemia susceptibility. METHODS Mothers of 158 children with Down syndrome diagnosed with acute leukemia at 0 to 19 years in 1997 to 2002 and 173 children with Down syndrome but no leukemia were interviewed. Associations were evaluated via multivariable unconditional logistic regression. RESULTS No association...

Abstract Background: Varicella is a highly contagious and dangerous disease especially in immunocompromised patients. Children with cancer are at increased risk of severe illness and may fatal cases occur. Vaccination from VZV ( varicella zoster vaccine) infection can be safe, immunogenic, and effective in children with leukemia who meet the criteria and are at the risk of serious disea...