Introduction: the context of Covid-19 pandemic in Brazilian North region is worrying. There a lack resources for Public Health, low human development index, and poverty indicators above national average. Objective: to analyze mortality lethality from COVID-19 State Roraima, Brazil. Methods: this an ecological time-series study secondary data on Northern Brazil, March 2020 July 2021. The inciden...

Some circularized X-Y chromosomes in Drosophila melanogaster are mitotically unstable and induce early embryonic lethality, but the genetic basis is unknown. Our experiments suggest that a large region of X-linked satellite DNA causes anaphase bridges and lethality when placed into a new heterochromatic environment within certain circularized X-Y chromosomes. These results reveal that repetitiv...

As we go into the 21st century, we can look at the past 30 years of domestic violence advocacy and research and remark proudly on how far we have come. The accumulated scientific knowledge, practitioner wisdom, policy changes, and public opinion changes are all remarkable (Klein, Campbell, Soler, & Ghez, 1997). What is even more exciting is that it looks like all that work has achieved at least...

We report that the anticancer activity of the widely used diabetic drug metformin is strongly potentiated by syrosingopine. Synthetic lethality elicited by combining the two drugs is synergistic and specific to transformed cells. This effect is unrelated to syrosingopine's known role as an inhibitor of the vesicular monoamine transporters. Syrosingopine binds to the glycolytic enzyme α-enolase ...

Systematic analysis of synthetic lethality (SL) constitutes a critical tool for systems biology to decipher molecular pathways. The most accepted mechanistic explanation of SL is that the two genes function in parallel, mutually compensatory pathways, known as between-pathway SL. However, recent genome-wide analyses in yeast identified a significant number of within-pathway negative genetic int...

Hybrid lethality is a deleterious phenotype that is vital to species evolution. We previously reported hybrid lethality in cabbage (Brassica oleracea) and performed preliminary mapping of related genes. In the present study, the fine mapping of hybrid lethal genes revealed that BoHL1 was located on chromosome C1 between BoHLTO124 and BoHLTO130, with an interval of 101 kb. BoHL2 was confirmed to...

OBJECTIVE This study was aimed at identifying the most common risk factors associated with suicide attempts to determine differences between risk factors present in patients regarding their low-lethality and high-fatality suicide attempts. METHOD 106 patients from both sexes who had been hospitalised in a psychiatric unit following their attempts at suicide were interviewed; they were divided...

High throughput imaging is used to assess hatching, lethality and malformations in zebrafish embryos suitable for hazard ranking of different nanomaterials.

Intensification of agricultural practices is one the most important drivers dramatic decline arthropod species. We do not know, however, relative contribution to different anthropogenic stressors that are part this process. used high-resolution dynamic landscape models and advanced spatially-explicit population modelling estimate importance insecticide use structure for dynamics a widespread ca...