BACKGROUND Momordica charantia (M. charantia) seed has been supposed to have an antifertility property but mechanisms underlying the infertility effect have not been investigated. OBJECTIVE We investigated the antifertility effect of M. charantia ethanol seed extracts on reproductive toxicology and seminal and plasma testosterone in male Wistar rats. MATERIALS AND METHODS The control group ...

The objective of this study was to compare (i) the intracytoplasmic sperm injection outcomes among groups with different total motile sperm count ranges, (ii) the intracytoplasmic sperm injection outcomes between groups with normal and abnormal total motile sperm count, and (iii) the predictive values of WHO 2010 cut-off values and pre-wash total motile sperm count for the intracytoplasmic sper...

We evaluated the effects of opiate consumption on semen quality, sperm function, seminal plasma antioxidant capacity, and sperm DNA integrity. A total of 142 opiate addict men (group 1) were enrolled in the study and 146 healthy age matched male volunteers (group 2) served as controls. Two semen analyses were performed in all participants. Sperm chromatin structure assay (SCSA) was used to iden...

OBJECTIVES To examine the clinical value of six seminal plasma components in the evaluation of sperm quality and in the differential diagnosis of men with infertility. METHODS We analyzed 202 seminal plasmas for prostate-specific antigen, glucose, pepsinogen C, insulin-like growth factor binding protein-3, prostaglandin D synthase (PGDS), and BRCA1-like immunoreactive protein (BRCA1-LIP) usin...

Background: A great number of substances have been found in sperm plasma but so far it has not been possible to provide evidence of clinical significance for all of them. Fructose occupies the most important place in biochemical investigations. Fructose acts as a donor of energy to the spermatozoa. Fructose is secreted from the seminal vesicles and the accessory sex glands. It is the major carb...

INTRODUCTION The exact causes of the decline in semen quality are not yet known, environmental factors have been considered to play an important role. Lead (Pb) and Cadmium (Cd) are two of the well-known reproductive toxicants to which humans are exposed occupationally and environmentally and can lead to negative effects on the testicular functions. The aim of this study was to evaluate lead an...

Background: ROS are free radicals that have a significant role in many of the sperm physiological processes. In the presence of polyunsaturated fatty acids such as sperm plasma membrane,ROS triggers a chain of chemical reactions called lipid peroxidation.The aim of this study was to determine and compare the concentration of MDA and NO in testicular extract of hyperprolactinemic adult male mice...

Many studies have reported that the contents of cigarette smoke negatively affect sperm parameters, seminal plasma, and various other fertility factors. Nevertheless, the actual effect of smoking on male fertility is not clear. The effect of smoking on semen parameters is based on the well-established biological finding that smoking increases the presence of reactive oxygen species, thereby res...

Background: There are several causes leading to male infertility, like oxidative stress, and nutritional deficiency of trace elements i.e., selenium and zinc. The Zinc is the following only to iron as the most abundant element in the body. Although, Zinc is found in red meat, white meat, fish, and milk; the World Health Organization (WHO) approximates that one-third of world population is defic...