background polypeptide hormone leptin suppresses inflammation in the heart muscle and protects heart from diseases. the purpose of this study is to evaluate the relationship between leptin and troponin serum levels with cardiac involvement in patients with major beta thalassemia. materials and methods in this cross-sectional study, 70 children with major thalassemia were selected. two ml blood ...

Abstract Introduction Individuals with obesity hypoventilation syndrome (OHS) are unable to increase ventilation match increased CO2 production (VCO2). Obstructive sleep apnea (OSA), defined by the closure of upper airway during sleep, is present in 90% OHS patients. Leptin, an adipocyte-produced hormone, acts leptin receptor (LEPRb) positive neurons and was implicated pathophysiology OSA OHS. ...

Introduction: Leptin is a critical metabolic signal linking nutrition and reproductive functions. Leptin receptors are expressed in germ cells, Sertoli and Leydig cells. Oxidative stress increases sperm DNA damages. Nitric oxide is a free radical, produced by most cells via Nitric Oxide (NO) synthase and plays stimulatory and inhibitory roles on cells. Physiological concentrations of NO are ess...

The purpose of this study was to evaluate the probable effects of leptin addition in different levels to the semen extender on sperm quality (motility and motility parameters, viability, sperm membrane integrity, and DNA damage). Semen specimens were evaluated immediately after leptin addition, equilibration time and after thawing the frozen semen. Five healthy buffalo bulls (5 ejaculates from ...

Objective: There are a few studies related to nitric oxide (NO) and leptin interaction in the regulation of physiological events skeletal muscle. Therefore, aim present study is investigate NO response blood flow synthase (NOS) distribution on rat Materials Methods: Twenty-four adult-male Wistar albino rats were divided into 4 groups: control (C), Leptin (LP) (50 μg/kg), L-NG-nitroarginine meth...

Leptin-resistant rats have reduced leptin receptors and signaling and are refractory to exogenous leptin. However, it is unclear how leptin-mediated hypothalamic signal transducer and activator of transcription 3 (STAT3) signaling relates to the loss of physiological responsiveness. We hypothesized that if leptin resistance is associated with leptin receptors that are no longer functionally cou...

Thermal stress is a unique and complex process which alters the normal physiological mechanisms. Heat shock proteins (HSPs) are known to be highly conserved ubiquitous synthesized in response several stimuli. The HSP inducers have been categorized as environmental (heat shock, UV radiation, heavy metals, amino acids, oxidative stress, etc.) pathological (bacterial or parasitic infections, fever...

background: the prevalence of vitamin d deficiency is higher in end-stage renal disease (esrd) patients compared to healthy populations. this deficiency could lead to several complications with different mechanisms and might result in reduced survival in patients. leptin and adiponectin are messenger proteins with endocrine secretion from adipocytes and various effects in cellular mechanisms. t...