introduction: lishmania is a protozoan parasite that cause visceral and cutaneous disease in man. this parasite shows two forms in its life cycle, amastigote in reticulo-endothelial cell of mammalian host and, promastigote in culture media and sand fly vector. like other kinetoplastide, leishmania has an extra chromosomal dna with unique topological and characteristic that called kdna. the orga...

Phlebotomine sand flies that transmit the protozoan parasite Leishmania differ greatly in their ability to support different parasite species or strains in the laboratory: while some show considerable selectivity, others are more permissive. In "selective" sand flies, Leishmania binding and survival in the fly midgut typically depends upon the abundant promastigote surface adhesin lipophosphogl...

Conventional methods for the identification of species of Leishmania parasite causing infections have limitations. By using a DNA-based alternative, the present study tries to develop a new tool for this purpose. Thirty-three patients living in Marseilles (in the south of France) were suffering from visceral or cutaneous leishmaniasis. DNA of the parasite in clinical samples (bone marrow, perip...

ABSTRACT        Background and Objective: Leishmania major is a flagellate protozoan parasite causing cutaneous leishmaniasis. Although pentavalent antimony compounds are the first-line drugs for leishmaniasis, their application is often accompanied by numerous limitations and side effects. Therefore, it is necessary to seek drugs of herbal origin that have fa...

background: characterization of leishmania parasites is necessary for epidemiological objectives such as documenting the distri­bution of predominant species and designing appropriate control measures. in this study, we aimed to identify leishma­nia species isolated from cutaneous leishmaniasis (cl) patients, using rapd-pcr method. methods: this descriptive, cross-sectional study was designed a...

background: zoonotic cutaneous leishmaniasis (zcl) due to leishmania major is increasing in many parts of iran. this disease originally is a disease found in gerbils. leishmania parasites are transmitted by sandflies that live and breed in gerbil burrows. nested pcr amplified leishmania its1-5.8s rrna gene in both main reservoir host “rhombomys opimus” and in the “phlebotomus papatasi” main vec...

BACKGROUND Autochthonous cutaneous and visceral leishmaniasis (VL) caused by Leishmania martiniquensis and Leishmania siamensis have been considered emerging infectious diseases in Thailand. The disease burden is significantly underestimated, especially the prevalence of Leishmania infection among HIV-positive patients. METHODS A cross-sectional study was conducted to determine the prevalence...

objective(s):to evaluate the effect of trinitroglycerin (tng) as nitric oxide donor agent on serum copper (cu) and zinc (zn) levels and liver enzymes in balb/c mice infected with leishmania major (l. major) mrho/ir/75/er. materials and methods: inbred female mice were divided into three groups: healthy group (uninfected naive mice), control group (infected with l. major), and test group (l. maj...

BACKGROUND Leishmania major complex is the main causative agent of zoonotic cutaneous leishmaniasis (ZCL) in the Old World. Phlebotomus papatasi and Phlebotomus duboscqi are recognized vectors of L. major complex in Northern and Southern Sahara, respectively. In Mali, ZCL due to L. major is an emerging public health problem, with several cases reported from different parts of the country. The m...