Angiomyoma is defined as a painful, benign subcutaneous or deep dermal tumor composed of mature smooth muscle bundles that are surrounded and interlaced by vascular channels. Smooth muscle neoplasms can be classified into solid leiomyomas, angioleiomyomas (vascular leiomyomas) and epitheloid leiomyomas (leiomyoblastomas). Among these types, the vascular leiomyoma is the most common subtype in t...

During colonoscopic examination, epithelial lesions, such as adenomatous polyps, are frequently encountered, unlike subepithelial lesions, such as leiomyomas, which are uncommon. A colonic leiomyoma is a rare tumor, originating either from the mucularis mucosa or from the proper muscle, and accounts for only 3% of all gastrointestinal leiomyomas. Colonic leiomyomas are usually benign and asympt...

BACKGROUND Papillary renal cell carcinoma is a rare cancer. Some cases can be attributed to individuals with hereditary renal cell carcinomas usually consisting of the clear cell subtype. In addition, two syndromes with hereditary papillary renal cell carcinoma have been described. One is the hereditary leiomyomatosis and renal cell carcinoma, which is characterized by cutaneous and uterine lei...

BACKGROUND Leiomyomas are benign tumours that originate from smooth muscles. They are often seen in the uterus, but also in the renal pelvis, bladder, spermatic cord, epididymis, prostate, scrotum or the glans penis. Leiomyomas of the tunica albuginea are extremely rare. CASE PRESENTATION A 59-year-old white male has noted an asymptomatic tumour on the right side of his scrotal sac for severa...

Esophageal leiomyomas are the most common benign mesenchymal esophageal tumors, but they occur rarely in the pediatric population. Leiomyomas are conventionally treated with extramucosal enucleation via an open thoracotomy. In this paper, we report a case of a complex massive retrocardiac esophageal leiomyoma that was successfully extirpated by using a robotic-assisted thoracoscopic technique. ...

Liomyomas of the nasal cavity and paranasal sinuses are rare. They make up less than 1% of all leiomyomas in the human body. This is due to the paucity of smooth muscle in the nose. They are classified in three groups: leiomyoma, angiomyoma and epithelioid leiomyoma. Only 15 cases of vascular leiomyomas have been found in the literature. The treatment of choice is surgical excision. Hereby we p...

Uterine leiomyomas (fibroids) are benign tumors that are prevalent in women of reproductive age. Research suggests that activated receptor tyrosine kinases (RTKs) play an important role in the enhanced proliferation observed in fibroids. In this study, a phospho-RTK array technique was used to detect RTK activity in leiomyomas compared with myometrial tissue. We found that fifteen out of sevent...

Uterine leiomyomas (ULs) are benign monoclonal tumors originating from myometrial tissue in the uterus. Genetic pathways that lead to myometrial transformation into leiomyomas are largely unknown. Approximately 40% of ULs are karyotypically abnormal by G-banding; however, the remaining 60% of leiomyomas do not contain cytogenetically visible genomic rearrangements. Recent technological advances...

tion of scant rectal bleeding that occurred with bowel movements. He deniedweight loss, fevers, fatigue, or alarm symptoms, and reported no family history of polyps, colorectal cancer, or intestinal disorders. His past medical history and physical examination including a digital rectal examination were unremarkable. Colonoscopy demonstrated a single 1.2 cm pedunculated polyp within the lumen of...

Unregulated proliferation of mesenchymal cells in leiomyomas, lipomas, hamartomas, and other diseases has been linked to the high mobility group (HMGA) family of DNA architectural proteins. HMGA genes are primarily expressed during embryonal development and silenced in adult tissues but can become reactivated in neoplasia as a result of chromosomal rearrangements. Although the genetic data sugg...