PURPOSE Small cell lung cancer (SCLC) possesses high tendency to disseminate. However, SCLC patients with paraneoplastic syndrome mediated by immunity against onconeural antigens remain in limited-stage disease (LD) without distant metastases. Cumulative evidence regulates that a balance between immune and regulatory T (Treg) cells determines the magnitude of immune responses to not only self-a...

Clinical manifestations of lactase (LCT) deficiency include intestinal and extra-intestinal symptoms. Lactose hydrogen breath test (H2-BT) is considered the gold standard to evaluate LCT deficiency (LD). Recently, the single-nucleotide polymorphism C/T(-13910) has been associated with LD. The objectives of the present study were to evaluate the agreement between genetic testing of LCT C/T(-1391...

Allograft rejection results from the specific recognition by host CD8+ T cells of allogeneic major histocompatibility complex (MHC) molecules on the tissue graft. The specificity of this cellular response is determined by the molecular interaction of the T-cell receptor (TCR) on host T cells with the MHC molecule and its bound ligand on the grafted tissue. To better understand the precise manne...

Perihypothalamic thyroid hormone signaling features prominently in the seasonal control of reproductive physiology. Triiodothyronine (T(3)) signaling stimulates gonadal development, and decrements in T(3) signaling are associated with gonadal regression. Type 3 iodothyronine deiodinase (DIO3) converts the prohormone thyroxine (T(4)) into biologically inactive 3,3',5'-triiodothyronine, and in lo...

Cytotoxic T lymphocytes provide protection against persistent infection of the central nervous system by the JHM strain of mouse hepatitis virus. In BALB/c (H-2d) mice, the dominant response is directed against an Ld-restricted peptide in the nucleocapsid protein (APTAGAFFF). Characterization of the fine specificity of this response revealed that the predicted anchor residues at positions 2 and...

Fol lowing the enormous increase in the use of wireless mobile telephony across the wor ld concerns on hea l th e f fec t s o f hand-he ld mobi le phone rad ia t ions have induced a l a rge body of research , bo th ep idemio log ica l and exper imenta l . Th is wi re less t echnology uses e lec t romagne t ic radiation in microwave range which may be harmful to human health. Parts of the radio ...

in this paper, we propose and evaluate a novel design of a lightly doped drain and source carbon nanotube field effect transistor (ldds-cntfet) with a negative differential resistance (ndr) characteristic, called negative differential resistance ldds-cntfet (ndr-ldds-cntfet). the device was simulated by using a non equilibrium green’s function method. to achieve this phenomenon, we have created...

Bu çal??mada, insan koryonik gonadotropini (hCG) ve prostaglandin F2-alfa (PGF2?) ile östruslar?n?n indüklenmesinden sonra gonadotropin salg?lat?c? hormon (GnRH) k?sa süreli progesteron uygulamas?n? takiben süperovulasyon uygulanan Hol?tayn donörler (modifiye protokol) klasik donörlerden elde edilen embriyolar?n kalitesi say?s? kar??la?t?r?ld?. Ara?t?rmada, üç ya?l? 20 adet ?rk? inek iki e?it g...

oral contraceptive pills have several side effects especially on the gastrointestinal tract and liver. absorption of low dose (ld) pills by the vaginal route avoids the first pass of the steroids through these tracts and probably has fewer side effects. this study was a cohort study for evaluation of side effects and acceptability of ld pills administered by the vaginal route. in a clinical tri...