BACKGROUND AND OBJECTIVES Studies have shown economic and clinical advantages of laparoscopic left-colon resections. Laparoscopic conversion to open is an important surgical outcome. We estimated conversion incidence, identified risk factors, and measured the clinical and economic impact. METHODS In this retrospective study, we used the Premier Perspective database to analyze left-sided colec...

We demonstrate that the immediate early 175K protein (IE175K) of herpes simplex virus type 1 binds to the cap site of the latency-associated promoter (LAP) in an unusual manner. The complex formed on the LAP cap site was significantly larger than that formed on the IE175K cap site and the requirements for binding were qualitatively distinct with respect to both the primary sequence determinants...

Paroxysmal nocturnal hemoglobinuria (PNH) and the stable phase of chronic myelogenous leukemia (CML) are the two hematological conditions known to be associated with low levels of leukocyte alkaline phosphatase (LAP) activity in peripheral blood polymorphonuclear cells (PMN). LAP mRNA levels were determined in PMN from PNH and CML patients by RNA blotting analysis. In CML, LAP mRNA is undetecta...

The leucocyte alkaline phosphatase (LAP) score of peripheral blood neutrophils was examined in 20 patients with multiple myeloma and compared with the score in 18 patients with monoclonal gammopathy of undetermined significance (MGUS). The mean (95% confidence limit) LAP score in those with multiple myeloma was 186 (169-218) compared with 92 (64-120) in the MGUS group. In the multiple myeloma g...

Interaction of Listeria monocytogenes with mammalian intestinal cells is believed to be an important first step in Listeria pathogenesis. Transposon (Tn916) mutagenesis provided strong evidence that a 104-kDa surface protein, designated the Listeria adhesion protein (LAP), was involved in adherence of L. monocytogenes to a human enterocyte-like Caco-2 cell line (V. Pandiripally, D. Westbrook, G...

To determine the prevalence of aggressive periodontitis and associated systemic manifestations in Moradabad district, Uttar Pradesh, India. 3000 patients, including 1872 males and 1128 females were evaluated with mean age of 30.99. The study population was classified into three groups: gingivitis, chronic periodontitis and aggressive periodontitis. Subjects with aggressive periodontitis were fu...

peripheral lymph nodes, located deep in the subcutaneous tissue, clean antigens from the extracellular fluid. generally, a normal sized lymph node is less than one cm in diameter. peripheral lymphadenopathy (lap) is frequently due to a local or systemic, benign, self-limited, infectious disease. however, it could be a manifestation of underlying malignancy. seventy-five percent of all laps are ...

The use of adult seat belts without booster seats in young children may lead to severe abdominal, lumbar or cervical spine and head and neck injuries. We describe four characteristic cases of lap belt injuries presenting to a tertiary children's hospital over the past year in addition to a review of the current literature. These four cases of spinal cord injury, resulting in significant long-te...

The recognition and clearance of dead cells is a process that must occur efficiently to prevent an autoimmune or inflammatory response. Recently, a process was identified wherein the autophagy machinery is recruited to pathogen-containing phagosomes, termed MAPLC3A (LC3)-associated phagocytosis (LAP), which results in optimal degradation of the phagocytosed cargo. Here, we describe the engageme...

In this paper, the lap splice length and the long-term (fatigue) performance of lap-spliced carbon FRP laminates were investigated. Lap-spliced CFRP coupon specimens were fabricated with a splice length of 12.7, 25.4, 38.1, 50.8, 76.2, and 101.6 mm. To eliminate the bending on the lap splice joint, a symmetric specimen configuration was adopted. The width of the specimens was 38.1 mm. These spe...